DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and kif2c

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_005163529.1	Gene:	kif2c / 100136875	ZFINID:	ZDB-GENE-070912-298	Length:	700	Species:	Danio rerio

Alignment Length:	726	Identity:	296/726 - (40%)
Similarity:	399/726 - (54%)	Gaps:	103/726 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDRIKIGEQLLFQRSDGRVHQVVCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIFAEN 65
            :.::.||..:...|||||:|..:....|:.:.::..||.|..:.|||||.::.|..:|..:....
Zfish     5 LSKLLIGLAVNISRSDGRIHSAIVKTANVSKSTVNVEWAEHGMTKGKEVDMNELNHLNSDLIQHL 69

  Fly    66 QP---------PISKP--------------------PSSLLPKPRGSSPTGGPKTH--------- 92
            ||         ||..|                    |::..|.|| ..|:..|.:.
Zfish    70 QPCHQEEPAPTPIPTPMTRMTKSVKASELPLRSSRIPTTSEPAPR-DCPSEEPASRRMTTRQTCL 133

  Fly    93 ----TGNPYAERMRVQDGRSKIATRKTDPAAVGAGNHELGRAHTPRVPAGRP--DRDAS------ 145
                ...|........|..|:.....|.|...|.....|.:..:|.:|:...  :.:||
Zfish   134 FRQPAPPPVVSASSADDVLSQNLPSSTIPKHSGYQRRLLSKPASPLLPSTEAICESEASKCAPMG 198

  Fly   146 PTQGRKSQGGNNSNQRFSSVVREVNRMKEQREKRRARQAEQLQEKDALRRNNPG--NPNWEVSVM 208
            |...|.||            |.|.|::..:|       ....:..||.:|...|  |.:.:...|
Zfish   199 PPSHRMSQ------------VSETNKVANKR-------LSIAKMPDAQKRGKFGETNRSKQFYQM 244

  Fly   209 LRQYRSTLIFSPLRCLDPNGGTVQQITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKV 273
            :.:||.|:...|:...||  ....:|.|||||||:::||...|.:|::|:|....|::||.:.||
Zfish   245 IEEYRETVQKVPMSLSDP--VKTHRICVCVRKRPLNKKELAKKEIDVVTIPGNGVLLLHEPKQKV 307

  Fly   274 DLTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFF 338
            ||||:||:..|.|||:|||:.:|.|||..||:||::|:||||.|||||||||||||||||||:|.
Zfish   308 DLTKYLENQTFHFDYSFDEDATNDLVYRFTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGDFS 372

  Fly   339 GKVQDCGTGIYAMAARDVFEEVSRPEYRQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDARQ 403
            ||.|:...||||:||:|||..:.:..|..|......:|||||..|||| ||..|..||||||.:|
Zfish   373 GKSQNSSKGIYALAAQDVFTLLRQKRYVDMDLCPYVTFFEIYNGKVFD-LLNKKTKLRVLEDEKQ 436

  Fly   404 QVVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHAVFQIALHFPDSWGPHGKCSF 468
            ||.||||.|:||:.|:||:::||.||..||||||.|||.||||||:.|:.|...:..  :||.|.
Zfish   437 QVNVVGLQEVPVSCVDDVIKMIERGSACRTSGQTFANASSSRSHAILQVILRRRNFL--YGKFSL 499

  Fly   469 VDLAGNERGADTQSADRQTRIEGAEINKSLLALKECIRALSRQSSHLPFRGSKLTQVLRDSFVGG 533
            |||||||||.|..|.||.|.:|.||||:||||||||||:|.:.|.|:|||.|||||||||||: |
Zfish   500 VDLAGNERGTDVSSNDRHTIVETAEINRSLLALKECIRSLGQNSEHIPFRMSKLTQVLRDSFI-G 563

  Fly   534 KKNKTCMIAMISPSMSCVENTLNTLRYADRVKEL--IAKEDEHLQSVEGDGEKSPDLNEE---SE 593
            :.::|||||||||.||..|.||||||||:|||||  |:|.|    :|| :|.|. :|:||   ||
Zfish   564 ENSRTCMIAMISPGMSSCEYTLNTLRYANRVKELNGISKGD----AVE-NGSKL-ELSEEGNSSE 622

  Fly   594 PEMMADE----EGDEEPEDEDNQHLTISSEEASSYNNMSYDMSFNHTLNILGPSRNVD--IQEVA 652
            .|.:..|    ....|.|:...:.|...||.|.|....|:|:..|.:        |:|  ::::.
Zfish   623 EETVLPEFEAISRVSEMEERFYEELKGCSEVAKSMELPSFDIVANLS--------NIDSFMRKLQ 679

  Fly   653 EQHALLVENLE 663
            |.:..|...:|
Zfish   680 ESYQALRSAIE 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	202/331 (61%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	199/326 (61%)
kif2c	XP_005163529.1	KISc_KIF2_like	267..595	CDD:276818	202/331 (61%)
kif2c	XP_005163529.1	Kinesin	273..596	CDD:278646	199/326 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.880