DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13544 and Aspm

DIOPT Version :9

Sequence 1:	NP_611761.1	Gene:	CG13544 / 37673	FlyBaseID:	FBgn0034826	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_033921.3	Gene:	Aspm / 12316	MGIID:	1334448	Length:	3122	Species:	Mus musculus

Alignment Length:	347	Identity:	87/347 - (25%)
Similarity:	133/347 - (38%)	Gaps:	96/347 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSKSSNCRLHLISRTGKLLLDYKQY----KAARTIQNNWRKFYFRKYFKDLRKAVITIQRWWRG- 93
            |...:.||:....|..:.   :|:|    ||...|:........|:.|..:|.|.|.|||.||.
Mouse  2601 SKVEAACRIQAWYRRWRA---HKKYLTLLKAVNIIEGYLSAQLARRRFLKMRAAAIIIQRKWRAT 2662

  Fly    94 FSVRKNHFRYVENLLQKRVQDHHHRAATKIQALFRGWKSRRT-IHDHSKLL------RKQVCAAE 151
            .|||...    |||  ||     ||||..|||.|||:::|:: :...|.:|      |..|.|.:
Mouse  2663 LSVRGAR----ENL--KR-----HRAACVIQAHFRGYQARQSFLQQRSAVLIIQRHVRAMVAAKQ 2716

  Fly   152 DLLNCVAFKLHHLLRTFAIPGVYSLKNSNCMSRVEKLLASLHFRFHNGRVKTQLAKELADRGKDT 216
            :.:..:                 .||.|..:  |:.|:.....|   .||..|.||        |
Mouse  2717 ERIKYI-----------------KLKKSTVV--VQALVRGWLVR---KRVSEQKAK--------T 2751

  Fly   217 ETFKRSNKFSKVPFEGARYWSQCKPKCEAALKM---------------------SKNIERRMYRI 260
            ..|.         |..|.|...|..|.:.|.::                     .|.::|:  |.
Mouse  2752 RLFH---------FTAAAYCHMCALKIQRAYRLHVTLRNAKKHMDSVIFIQRWFRKRLQRK--RF 2805

  Fly   261 IEIYD---ASQREAHAALVEKNRAYRKHKGLMQNIKKSAEKSKRDFCGDVIASMRR---WKILVD 319
            ||.|.   :::|||||..::::||....:..::.......:.|...|...|.::.|   |:  ..
Mouse  2806 IEQYHKILSTRREAHACWLQQDRAASVIQKAVRRFLLCRRQEKITSCATRIQALWRGYSWR--KK 2868

  Fly   320 NDLTVDKNIFKNPQNLERFVAE 341
            ||.|..|.|.::.:.:...|.|
Mouse  2869 NDHTEIKAIRRSLRAVSTTVEE 2890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13544	NP_611761.1	COG5022	<12..>301	CDD:227355	75/302 (25%)
Aspm	NP_033921.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		ASH	29..126	CDD:292408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..169
		Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000269\|PubMed:28436967	289..388
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..600
		CH	928..1024	CDD:294029
		CH	1082..>1135	CDD:278723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8171
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950