Protein Alignment Klp59C and KIF2B

DIOPT Version :9

• Sequence 1: NP_611759.1
• Gene: Klp59C / 37671
• FlyBaseID: FBgn0034824
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_115948.4
• Gene: KIF2B / 84643
• HGNCID: 29443
• Length: 673
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 260/566 - (45%)
• Similarity: 368/566 - (65%)
• Gaps: 45/566 - (7%)

  Fly     6 IEQKIF--IRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPHIFD---- 64
            |::.|:  |:|||.|:|||.:.:: ..::..:||||.|....:||::.||.::|:||.:..
Human    26 IQEGIYVAIQRSDKRIHLAVVTEI-NRENYWVTVEWVEKAVKKGKKIDLETILLLNPALDSAEHP 89

  Fly    65 ------SPRCSGGNAASANQ---TASISPRSMKQRIATGSLSPVLATAPP---RQQTAPPVREDE 117
                  ||.....::|..:|   |..::....|.:.|:|....|...:.|   :|:.:|
Human    90 MPPPPLSPLALAPSSAIRDQRTATKWVAMIPQKNQTASGDSLDVRVPSKPCLMKQKKSP------ 148

  Fly   118 VVHQAERMRKERERRREAQARTRLDREQGKNEDPGNPNWEVARMIRLQREQMESQRVRSGTTNER 182
            .:.:.::::::||:||..|...|..|....|  ..|||:|:..||...|..::|.::   :..|.
Human   149 CLWEIQKLQEQREKRRRLQQEIRARRALDVN--TRNPNYEIMHMIEEYRRHLDSSKI---SVLEP 208

  Fly   183 INCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEE 247
            ...|:|.||||||||.::|...::.|::::||.:.::|||.::.|:|.::|:|.:|.||:.||::
Human   209 PQEHRICVCVRKRPLNQRETTLKDLDIITVPSDNVVMVHESKQKVDLTRYLQNQTFCFDHAFDDK 273

  Fly   248 CSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFS 312
            .||..||:|||:||::.||..|||||||||||||||||||||.|.|..|....||||:.|:|||.
Human   274 ASNELVYQFTAQPLVESIFRKGMATCFAYGQTGSGKTYTMGGDFSGTAQDCSKGIYALVAQDVFL 338

  Fly   313 TLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLD 377
            .|:...|.||:||||.:||||||.:|:||| ..|.:|:||||.|||:|||||.:..|....|||:
Human   339 LLRNSTYEKLDLKVYGTFFEIYGGKVYDLL-NWKKKLQVLEDGNQQIQVVGLQEKEVCCVEEVLN 402

  Fly   378 LLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKFSLIDLAGNERGADNSSADRQTR 442
            |:|:|||.|||..|..|:.||||||||||:|:|  |..:||||||:||||||||||.:.|.|:.:
Human   403 LVEIGNSCRTSRQTPVNAHSSRSHAVFQIILKS--GRIMHGKFSLVDLAGNERGADTTKASRKRQ 465

  Fly   443 LEGSEINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHSVEH 507
            |||:|||||||.|||||.|||:...|.|||.||||.||||||| |:...|||||.|||.:.|.|:
Human   466 LEGAEINKSLLALKECILALGQNKPHTPFRASKLTLVLRDSFI-GQNSSTCMIATISPGMTSCEN 529

  Fly   508 TLNTLRYADRVKELSVESIP-----------SKRMPDANLGSTSMS 542
            ||||||||:|||:|:|:..|           :.||..:::|::.||
Human   530 TLNTLRYANRVKKLNVDVRPYHRGHYPIGHEAPRMLKSHIGNSEMS 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	198/331 (60%)
		Kinesin	193..520	CDD:278646	195/326 (60%)
KIF2B	NP_115948.4	KISc_KIF2_like	213..541	CDD:276818	198/331 (60%)
		Kinesin	219..541	CDD:278646	194/325 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.780