DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59C and Kif2a

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_445828.1	Gene:	Kif2a / 84391	RGDID:	70974	Length:	705	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	291/607 - (47%)
Similarity:	377/607 - (62%)	Gaps:	64/607 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KLSIEQKIFIRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPHIF---- 63
            |:.|...:.|:|||||:|.|.:..| ..|::.:||||.|....:|||:.||.:..:||.:.
  Rat     8 KIQIGIYVEIKRSDGRIHQAMVTSL-NEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDED 71

  Fly    64 -------------------------------DSPRCSGGNAASANQTASISPRSMKQRIATGSLS 97
                                           |.|........||....|..|.........||:|
  Rat    72 IEPSPEIPPPSSSSKVNKIVKNRRTVASIKNDPPPRDNRVVGSARARPSQLPEQSSSAQQNGSVS 136

  Fly    98 PVLATAPPRQQTAPPV-REDEVVHQAERMRKERERRREAQARTRLDREQGKNEDPGNPNWEVARM 161
            .:......:::..||. |:...|.:.|:::::||:||..|...|..|.|  :.|..|||:|:..|
  Rat   137 DISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQ--DVDATNPNYEIMCM 199

  Fly   162 IRLQREQMESQRVRSGTTNERINCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKH 226
            ||..|..::   .|..||.:.|:.|:|.||||||||.:||...::.||::||||..::||||::.
  Rat   200 IRDFRGSLD---YRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQK 261

  Fly   227 VNLVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQF 291
            |:|.::|||.:|||||.||:...|..||.||||||::.||:.||||||||||||||||:||||.|
  Rat   262 VDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDF 326

  Fly   292 PGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRN 356
            .|::|....||||:||:|||..||...|.||.|:||.:|||||..:||||| ..|.:||||||..
  Rat   327 SGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLL-NRKTKLRVLEDGK 390

  Fly   357 QQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKFS 421
            ||||||||.:..|:...:||.|:::|||.||||.||||:.||||||||||:||...  |||||||
  Rat   391 QQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KLHGKFS 453

  Fly   422 LIDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIG 486
            ||||||||||||.|||||||||||:|||||||.||||||||||...|.|||.||||||||||||
  Rat   454 LIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFI- 517

  Fly   487 GKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKELSVESI-----------PSKRMPDA----NL 536
            |:..:|||||.|||.:.|.|:||||||||:|||||:|:..           |..::.|.    .:
  Rat   518 GENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPTAAGDVRPIMHHPPSQIDDLETQWGV 582

  Fly   537 GSTSMSD---IVCQSSTQRLFP 555
            ||:...|   ::|:.:.:.:.|
  Rat   583 GSSPQRDDLKLLCEQNEEEVSP 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	219/331 (66%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	216/326 (66%)
Kif2a	NP_445828.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..185		21/119 (18%)
Kif2a	NP_445828.1	KISc_KIF2_like	222..550	CDD:276818	219/331 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920