Protein Alignment Klp59C and Kif2c

DIOPT Version :10

• Sequence 1: NP_611759.1
• Gene: Klp59C / 37671
• FlyBaseID: FBgn0034824
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_608301.3
• Gene: Kif2c / 73804
• MGIID: 1921054
• Length: 721
• Species: Mus musculus
• Alignment Length: 682
• Identity: 295/682 - (43%)
• Similarity: 397/682 - (58%)
• Gaps: 115/682 - (16%)

  Fly     5 SIEQKIF------IRRSDGRVHLAEI--IKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPH 61
            |:..::|      |:||:|.:|.|.|  :.:|   ...::|||.||.|.:|||:.::.|..:||.
Mouse     3 SLHARLFPGLSINIQRSNGLIHPANISTVNVE---KSCVSVEWIEGGTTKGKEIDIDDVAAINPE 64

  Fly    62 IF--------DS---------------------PRCSGGNAASANQTASIS-------------- 83
            :.        ||                     |....|..:.:.:.:::|
Mouse    65 LLQLLPLRPKDSLPLQENVTVPKQKRKSVNSKIPALKEGLRSRSTRMSTVSEVRIPAQENEMEVE 129

  Fly    84 ---PRSMKQRIA----------TGSLSPVLATAPPRQQTAPPVREDE-------------VVHQA 122
               |.:.:::.|          |.:..|:|..:...::.|...|...             :|.:.
Mouse   130 LPVPTNSRKQFAIPSHPRASCSTVTELPLLMVSEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEM 194

  Fly   123 ERMRKERERRREAQARTRLDREQGKNEDPGNPNWEVARMIRLQREQMESQRVRSGTTNERINCHQ 187
            |:|:.:||.:|...:..|:.|.|  ..|...||||.||||:..|..||...:   |..:.|..|:
Mouse   195 EKMKNKREEKRAQNSELRIKRAQ--EYDSSFPNWEFARMIKEFRVTMECSPL---TVTDPIEEHR 254

  Fly   188 IMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNAT 252
            |.||||||||.::|||.:|.||:|:|||..|:||||:..|:|.|:|||.:|.||:.|||..||..
Mouse   255 ICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEV 319

  Fly   253 VYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKTV 317
            ||.||||||::.||:||.||||||||||||||:||||...|:.|::..||||||::||| .||..
Mouse   320 VYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVF-LLKNQ 383

  Fly   318 P-YNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLEL 381
            | |..|||:||.:|||||..:|||||.. |.:||||||..||||||||.:..|....:|:.::.:
Mouse   384 PRYRNLNLEVYVTFFEIYNGKVFDLLNK-KAKLRVLEDSRQQVQVVGLQEYLVTCADDVIKMINM 447

  Fly   382 GNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKFSLIDLAGNERGADNSSADRQTRLEGS 446
            |::.||||.|.|||.||||||.|||:||:..  :|||||||:||||||||||.||||||||:||:
Mouse   448 GSACRTSGQTFANSNSSRSHACFQILLRTKG--RLHGKFSLVDLAGNERGADTSSADRQTRMEGA 510

  Fly   447 EINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHSVEHTLNT 511
            |||||||.|||||||||:..:|.|||.|||||||||||| |:..:|||||||||.:.|.|:||||
Mouse   511 EINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFI-GENSRTCMIAMISPGISSCEYTLNT 574

  Fly   512 LRYADRVKELSVESIPSKRMPDANLGSTSMSDIVCQSSTQRLFPCASSTSMPGGGNQAQQHTNTA 576
            |||||||||||..|.||...|             .|..|:.:...::.||:.  ||:.::.::..
Mouse   575 LRYADRVKELSPHSGPSGEQP-------------VQMETEVMEASSNGTSLT--GNEEEELSSQM 624

  Fly   577 NDLNRSQKPTSKPTYPTSGQQLVQRKGSSQRE 608
            :..|.:.         |..::|.:|.....||
Mouse   625 SSFNEAM---------TQIRELEERALEELRE 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	216/332 (65%)
Kif2c	NP_608301.3	Globular. /evidence=ECO:0000255	1..250		56/254 (22%)
		Microtubule tip localization signal	95..98		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	164..188		2/23 (9%)
		Negative regulator of microtubule-binding	203..234		13/32 (41%)
		KISc_KIF2_like	254..582	CDD:276818	216/332 (65%)