DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59C and Kif2b

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_082823.1	Gene:	Kif2b / 73470	MGIID:	1920720	Length:	668	Species:	Mus musculus

Alignment Length:	573	Identity:	277/573 - (48%)
Similarity:	373/573 - (65%)	Gaps:	50/573 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IFIRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPHIFD---------- 64
            :.|:|||.|:|||.:.:: ..::..:||||.|....:||::.||.|:|:||.:..
Mouse    32 VAIQRSDKRIHLAVVTEI-NRENSWVTVEWVEKGVKKGKKIELETVLLLNPALASLEHQRSRRPL 95

  Fly    65 -----SPRCSGGNAASANQTASISPRSMKQRIATGSLSPVLATAPP---RQQTAPPVREDEVVHQ 121
                 .|..:.|:..:|.:..::.|.  :....:|....::..:.|   :::.:|.:||
Mouse    96 RPVSVVPSTAIGDQRTATKWIAMIPH--RNETPSGDSQTLMIPSNPCLMKRKKSPCLRE------ 152

  Fly   122 AERMRKERERRREAQARTRLDREQGKNEDPGNPNWEVARMIRLQREQMESQRVRSGTTNERINCH 186
            .|:::|:||:||..|...|..|....|  .||||:|..|||...|.:::|.::.|....|.   |
Mouse   153 IEKLQKQREKRRRLQLEIRARRALDIN--TGNPNFETMRMIEEYRRRLDSSKMSSLEPPED---H 212

  Fly   187 QIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNA 251
            :|.||||||||.::|...::.|:::|||.:.::|||.::.|:|.::|||.:|.||:.||::.||.
Mouse   213 RICVCVRKRPLNQRETTMKDLDIITIPSHNVVMVHESKQKVDLTRYLENQTFCFDHAFDDKASNE 277

  Fly   252 TVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKT 316
            .||:||||||::.||..||||||||||||||||:||||.|.|:.|....||||:.|:|||..|||
Mouse   278 LVYQFTARPLVESIFRKGMATCFAYGQTGSGKTHTMGGAFLGKAQDCSKGIYALVAQDVFLLLKT 342

  Fly   317 VPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLEL 381
            ..|.||.||||.:||||||.:|:||| ..|.:|:||||.|||||||||.:..|....|||:|:||
Mouse   343 PAYEKLELKVYGTFFEIYGGKVYDLL-NWKKKLQVLEDGNQQVQVVGLQEQEVSCVEEVLNLVEL 406

  Fly   382 GNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKFSLIDLAGNERGADNSSADRQTRLEGS 446
            |||.||||.||.|:.|||||||||::|:  ||.||||||||:||||||||||.:.|.|:.:|||:
Mouse   407 GNSCRTSGQTSVNAHSSRSHAVFQLILK--AGGKLHGKFSLVDLAGNERGADTAKATRKRQLEGA 469

  Fly   447 EINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHSVEHTLNT 511
            |||||||.|||||||||:..||.|||.|||||||||||| |:...|||||.|||.:.|.|:||||
Mouse   470 EINKSLLALKECIRALGKNKSHTPFRASKLTQVLRDSFI-GQNSYTCMIATISPGMTSCENTLNT 533

  Fly   512 LRYADRVKELSVE--------SIPSKRMP------DANLGSTSMSDIVCQSST 550
            ||||:|||||::|        |.|...:|      :.|.|.:...|.|.|..|
Mouse   534 LRYANRVKELALEARPYHHCVSPPGHEVPLMIENDNTNSGKSLQRDEVIQIPT 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	210/331 (63%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	207/326 (63%)
Kif2b	NP_082823.1	KISc_KIF2_like	213..541	CDD:276818	210/331 (63%)
		Kinesin	219..542	CDD:278646	207/326 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..605		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780