DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59C and Kif3C

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	145/469 - (30%)
Similarity:	208/469 - (44%)	Gaps:	79/469 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 IMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNAT 252
            |.|.||.||:.:.|.....|::|.| ::..:.|..|...::     :...|.||.|::.:.....
  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEI-NEFAVSVTNPSARIS-----QQKKFIFDSVYNMKTDTEV 63

  Fly   253 VYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLK-T 316
            :|:.....|::...:|...|.|||||||.|||:||.|.   .:.|:..||.......:|..:. |
  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGD---ENFSNSTGIIPKCFDHIFERISMT 125

  Fly   317 VPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVG---------------LTQ 366
            .....|.|..|   .|||..|:.|||           ::|:...|:.               ||.
  Fly   126 TNVRYLALVTY---LEIYNERIRDLL-----------NKNENTNVINHFLKELPGIGVSVPTLTT 176

  Fly   367 NPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLR----------SAAGEKLHGKFS 421
            .||.|..:..|.|..||..|.:..|..|..|||||.:|.|.|.          .|.|....||.|
  Fly   177 QPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLS 241

  Fly   422 LIDLAGNERGADNSSADRQTRL-EGSEINKSLLVLKECIRAL-GRQSSHLPFRGSKLTQVLRDSF 484
            |:||||:||  ...:..:..|| |.|:||.||..|...|.:| ..::.|:|||.||||::|:||
  Fly   242 LVDLAGSER--QRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDS- 303

  Fly   485 IGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKELSVESIPSKRMPDANLGSTSMSDIVCQSS 549
            :|| ..||.||:.|||.....:.|::|||||.|.|.:|.:...::...||.|.......:..:..
  Fly   304 LGG-NTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRM 367

  Fly   550 TQRLFPCASSTSMPG----GGNQAQQHTN---TAN----DLNRSQKPT--------SKPTYPTSG 595
            .|......:..:.|.    ...:..||||   |.|    ||.|:.|.:        :||.:|
  Fly   368 LQESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFP--- 429

  Fly   596 QQLVQRKGSSQREA 609
              |:|.|...|.:|
  Fly   430 --LIQSKEEVQLQA 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	120/358 (34%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	117/354 (33%)
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	121/360 (34%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	118/355 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030