DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp59C and Klp61F

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	144/470 - (30%)
Similarity:	226/470 - (48%)	Gaps:	72/470 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 VRSGTTN---ERINCHQIMVCVRKRPLRRKELADREQDVV------SIPSKHTLVVHEPRKHVNL 229
            :..|.|:   ::.:...|.|.||.|||..:|...|..:||      .:.::|||.....:|
  Fly     3 ISGGNTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKK---- 63

  Fly   230 VKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGR 294
                    |.||..|..|.....||.....|||:.:.:|...|.|||||||:|||:||.|.....
  Fly    64 --------FTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAE 120

  Fly   295 HQSSMD-----GIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLL-MPGKPQLRVLE 353
            .:||.:     ||...|...:|..|:.:   ::...:..|:.|:|...:.||| .....::|:.:
  Fly   121 LKSSWEDDSDIGIIPRALSHLFDELRMM---EVEYTMRISYLELYNEELCDLLSTDDTTKIRIFD 182

  Fly   354 DRNQQVQVV--GLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVL----RSAA 412
            |..::..|:  ||.:.||.:..:|..|||.|...|.:..|..|::|||||.||.||:    ....
  Fly   183 DSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIE 247

  Fly   413 GEKL--HGKFSLIDLAGNERGADNSSADRQTRL-EGSEINKSLLVLKECIRALGRQSSHLPFRGS 474
            ||.:  .||.:|:||||:| ....:..::..|: |...||:|||.|...|.||..::.|:|:|.|
  Fly   248 GEDMLKIGKLNLVDLAGSE-NVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRES 311

  Fly   475 KLTQVLRDSFIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKELSVESIPSKRMPDANLGST 539
            |||::|::| :|| :.||.:||.|||....:|.||:||.||.|.|.:       :..|:.|...|
  Fly   312 KLTRLLQES-LGG-RTKTSIIATISPGHKDIEETLSTLEYAHRAKNI-------QNKPEVNQKLT 367

  Fly   540 SMSDIVCQSSTQRLFPCASSTSMPGGGNQAQQHTNTANDLNRSQKPTSKPTYPTSGQQLVQRKGS 604
            ..:  |.:..|:.:             ::.::....|.|.|...  .::.||    .::..:..|
  Fly   368 KKT--VLKEYTEEI-------------DKLKRDLMAARDKNGIY--LAEETY----GEITLKLES 411

  Fly   605 SQREAS--MMLTKSL 617
            ..||.:  |:|.|:|
  Fly   412 QNRELNEKMLLLKAL 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	124/352 (35%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	121/347 (35%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	127/372 (34%)
		Kinesin	25..356	CDD:278646	122/348 (35%)
		Microtub_bind	923..>1009	CDD:290642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840