Protein Alignment Klp59C and KIF2A

DIOPT Version :10

• Sequence 1: NP_611759.1
• Gene: Klp59C / 37671
• FlyBaseID: FBgn0034824
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_001091981.1
• Gene: KIF2A / 3796
• HGNCID: 6318
• Length: 744
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 295/581 - (50%)
• Similarity: 373/581 - (64%)
• Gaps: 55/581 - (9%)

  Fly     3 KLSIEQKIFIRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNP------H 61
            |:.|...:.|:|||||:|.|.:..| ..|::.:||||.|....:|||:.||.:..:||      .
Human     8 KIQIGIYVEIKRSDGRIHQAMVTSL-NEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDEE 71

  Fly    62 IFDSPRCSGGNAASA---------NQTASI--SPRSMKQRIA-------------------TGSL 96
            |..||......|:||         ...|||  .|.|...|:.                   .||:
Human    72 IEPSPETPPPPASSAKVNKIVKNRRTVASIKNDPPSRDNRVVGSARARPSQFPEQSSSAQQNGSV 136

  Fly    97 SPVLATAPPRQQTAPPV-REDEVVHQAERMRKERERRREAQARTRLDREQGKNEDPGNPNWEVAR 160
            |.:......:::..||. |:...|.:.|:::::||:||..|...|..|.|  :.|..|||:|:..
Human   137 SDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQ--DVDATNPNYEIMC 199

  Fly   161 MIRLQREQMESQRVRSGTTNERINCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRK 225
            |||..|..::   .|..||.:.|:.|:|.||||||||.:||...::.||::||||..::||||::
Human   200 MIRDFRGSLD---YRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQ 261

  Fly   226 HVNLVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQ 290
            .|:|.::|||.:|||||.||:...|..||.||||||::.||:.||||||||||||||||:||||.
Human   262 KVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGD 326

  Fly   291 FPGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDR 355
            |.|::|....||||:||:|||..||...|.||.|:||.:|||||..:||||| ..|.:||||||.
Human   327 FSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLL-NRKTKLRVLEDG 390

  Fly   356 NQQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKF 420
            .||||||||.:..|:...:||.|:::|||.||||.||||:.||||||||||:||...  ||||||
Human   391 KQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KLHGKF 453

  Fly   421 SLIDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFI 485
            |||||||||||||.|||||||||||:|||||||.||||||||||...|.|||.||||||||||||
Human   454 SLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFI 518

  Fly   486 GGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKE--LSVESIPSKRMPDANLGSTSMSDI 544
             |:..:|||||.|||.:.|.|:||||||||:||||  :|...||..:      ||.|..|:
Human   519 -GENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDIPFSQ------GSGSRPDL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	219/331 (66%)
KIF2A	NP_001091981.1	KISc_KIF2_like	223..551	CDD:276818	219/331 (66%)