DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp59C and Kif24

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_077203.2	Gene:	Kif24 / 109242	MGIID:	1918345	Length:	1356	Species:	Mus musculus

Alignment Length:	617	Identity:	236/617 - (38%)
Similarity:	333/617 - (53%)	Gaps:	76/617 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LAEIIKLEGGDSKLITVEWPEGHTVRGKEL---PLELVVLMNP----HIFDSPRCSGGNAASANQ 78
            |.:|||:...:.|.:.:  || |.::...|   |.|.  ...|    | ||||..|....|: |:
Mouse    57 LIKIIKIMQEEDKALGI--PE-HPLQASSLYTKPREF--RSGPRRQLH-FDSPSASKDKMAN-NE 114

  Fly    79 TASISPRSMKQRIATGSLSPVLATAPPRQQTAPPVREDEVVHQAERMRKERER------------ 131
            |.|:|..|:.::.:| .|..:....|...|....:|..:.......|:.|...
Mouse   115 TGSLSNFSVDEQKST-YLKVLEHMLPDDSQCQTKIRAPDASAADASMQTETNAPLFSSNYFSPQL 178

  Fly   132 -RREAQARTRLDREQGKNEDPGNPNWEVARMIRLQREQMESQRVRSGTTNERINCHQIMVCVRKR 195
             ..:.....|:....|.|.  |.|: ...|.|..:....|.:::|              ||||||
Mouse   179 GNCDIPVIQRVSHVSGYNY--GIPH-SCVRQITSENPWTEMEKIR--------------VCVRKR 226

  Fly   196 PLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNATVYEFTARP 260
            ||..:|:...|.:|:::..|.||:|||.::.|:|.:::..|.|.||.||.|.|||..||..||.|
Mouse   227 PLGVREVRRGEVNVITVEDKETLLVHEKKEAVDLTQYILQHVFYFDEVFGEACSNQDVYLKTAHP 291

  Fly   261 LIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLK 325
            ||:|||:||.||||||||||:||||||    .|.||:  .|:||:||||:|..|| |..::.||.
Mouse   292 LIQHIFNGGSATCFAYGQTGAGKTYTM----IGTHQN--PGLYALAAKDIFRQLK-VSQSRRNLF 349

  Fly   326 VYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGH 390
            |:.||:|||..:::|||...| :|...||....||:.||.:..|.:...:|.::..|:..|::|.
Mouse   350 VWISFYEIYCGQLYDLLNRRK-RLFAREDSKHVVQIAGLRELQVDSVELLLQVILKGSKERSTGA 413

  Fly   391 TSANSKSSRSHAVFQIVLRSAAGEKLHGKFSLIDLAGNERGADNSSADRQTRLEGSEINKSLLVL 455
            |..|:.||||||:.||.::.:| ::..|:.|.|||||:||.||...:||||::||:|||:|||.|
Mouse   414 TGVNADSSRSHAIIQIQIKDSA-KRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLAL 477

  Fly   456 KECIRALGRQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKE 520
            |||||||.::.:|.|||.|||||||:|||||  ..||||||.|||...:.|||||||||||||||
Mouse   478 KECIRALDQEHTHTPFRQSKLTQVLKDSFIG--NAKTCMIANISPSHIATEHTLNTLRYADRVKE 540

  Fly   521 LSVESIPSKRMPDANLGSTSMSDIVCQSSTQRLFPCASSTSMPGGG-NQAQQHTNTANDLNRSQK 584
            |       |:.......:||.:.....:|.:|:  .:|..::||.. :..:........|..:..
Mouse   541 L-------KKGVKCCASATSQNQTSANASPKRI--QSSPVTLPGDKCSPKKVKLGLQQSLTVAPG 596

  Fly   585 PTSKPTYP----------TSGQQLVQRKGSSQ 606
            ||....:|          |||.:...:|.||:
Mouse   597 PTKVKAHPLASHVPNVPFTSGPKTPGKKSSSR 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	174/331 (53%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	172/326 (53%)
Kif24	NP_077203.2	SAM_KIF24-like	3..62	CDD:188940	2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..119		11/27 (41%)
		KISc_KIF2_like	218..539	CDD:276818	175/345 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..581		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..664		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	788..840
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..947
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..998
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1140
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.640