DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59C and kif2a

DIOPT Version :9

Sequence 1:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_002934245.2	Gene:	kif2a / 100379688	XenbaseID:	XB-GENE-951755	Length:	745	Species:	Xenopus tropicalis

Alignment Length:	583	Identity:	294/583 - (50%)
Similarity:	375/583 - (64%)	Gaps:	57/583 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KLSIEQKIFIRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPHIFDSPR 67
            |:.|...:.|:|||||:|.|.:..| ..||:.|||||.|....:|||:.||.:..:||.:.....
Frog     7 KIHIGIYVEIKRSDGRIHQAMVTSL-NEDSESITVEWIENGDTKGKEIDLESIFSLNPDLAPDEE 70

  Fly    68 CSGG-----------------------------NAASANQTASIS-----PRSMKQRIAT----G 94
            ...|                             ..|..|:.|::|     |....::.|:    |
Frog    71 IDPGPEMPPPPTPTTKVNKIVKNRRTVAPVKNETPARDNRVAAVSSARARPSQPIEQSASAQQNG 135

  Fly    95 SLSPVLATAPPRQQTAPPV-REDEVVHQAERMRKERERRREAQARTRLDREQGKNEDPGNPNWEV 158
            |:|.:....|.::...||. |:...|.:.|:::::||:||..|...|  .::.::.|..|||:|:
Frog   136 SVSDISPDQPGKKDFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELR--EKKAQDVDATNPNYEI 198

  Fly   159 ARMIRLQREQMESQRVRSGTTNERINCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEP 223
            ..||:..|..::   .|..||.:.|:.|:|.||||||||.:||...::.||::||||..::||||
Frog   199 MCMIKDFRGSLD---YRPLTTADTIDEHRICVCVRKRPLNKKENTVKDLDVITIPSKDVVMVHEP 260

  Fly   224 RKHVNLVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMG 288
            ::.|:|.:||||.:|||||.|||...|..||.||||||::.||:.||||||||||||||||:|||
Frog   261 KQKVDLTRFLENQTFRFDYAFDETAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMG 325

  Fly   289 GQFPGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLE 353
            |.|.|::|....||||:||:|||..||...|.||.|:||.:|||||..:||||| ..|.:|||||
Frog   326 GDFSGKNQDCSKGIYALAARDVFQMLKKPNYKKLELQVYATFFEIYSGKVFDLL-NRKTKLRVLE 389

  Fly   354 DRNQQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHG 418
            |..||||||||.:..|:...:||.|:|:|||.||||.||||:.||||||||||:||...  ||||
Frog   390 DGKQQVQVVGLQEREVKCVEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KLHG 452

  Fly   419 KFSLIDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDS 483
            |||||||||||||||.|||||||||||:|||||||.||||||||||...|.|||.||||||||||
Frog   453 KFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDS 517

  Fly   484 FIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKE--LSVESIPSKRMPDANLGSTSMSDI 544
            || |:..:|||||.|||.:.|.|:||||||||:||||  :|...||..:      ||.|.||:
Frog   518 FI-GENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDIPFSQ------GSGSRSDL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	222/331 (67%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	219/326 (67%)
kif2a	XP_002934245.2	KISc_KIF2_like	224..552	CDD:276818	222/331 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3177
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040