DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpL37b and KCNQ4

DIOPT Version :9

Sequence 1:	NP_611757.1	Gene:	RpL37b / 37669	FlyBaseID:	FBgn0034822	Length:	89	Species:	Drosophila melanogaster
Sequence 2:	NP_004691.2	Gene:	KCNQ4 / 9132	HGNCID:	6298	Length:	695	Species:	Homo sapiens

Alignment Length:	67	Identity:	18/67 - (26%)
Similarity:	21/67 - (31%)	Gaps:	24/67 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RRCGNSSYHL------QKSKCSQCGYPAAKTR-SFNWSRKAKGRKAQGTGRMRYLKNLRRRFRNG 77
            ||.|.|..||      ......|.|...:.|: ..:||                 .|.|.|||..
Human   447 RRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWS-----------------FNDRTRFRAS 494

  Fly    78 LR 79
            ||
Human   495 LR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpL37b	NP_611757.1	PTZ00073	1..89	CDD:240257	18/67 (27%)
KCNQ4	NP_004691.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		MIG-14_Wnt-bd	<92..190	CDD:284153
		Ion_trans	126..330	CDD:278921
		Ion_trans_2	246..320	CDD:285168
		Selectivity filter. /evidence=ECO:0000250	283..288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..480		9/32 (28%)
		KCNQ_channel	474..653	CDD:281513	10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..515		1/1 (100%)
		A-domain (Tetramerization)	546..650
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900