DRSC/TRiP Functional Genomics Resources

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Protein Alignment RpL37b and KCND2

DIOPT Version :9

Sequence 1:NP_611757.1 Gene:RpL37b / 37669 FlyBaseID:FBgn0034822 Length:89 Species:Drosophila melanogaster
Sequence 2:NP_036413.1 Gene:KCND2 / 3751 HGNCID:6238 Length:630 Species:Homo sapiens


Alignment Length:15 Identity:5/15 - (33%)
Similarity:10/15 - (66%) Gaps:0/15 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 CGNSSYHLQKSKCSQ 36
            ||:|..|:::..|.:
Human   209 CGSSPGHIKELPCGE 223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpL37bNP_611757.1 PTZ00073 1..89 CDD:240257 5/15 (33%)
KCND2NP_036413.1 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
Shal-type 3..28 CDD:288455
BTB_2 43..132 CDD:308049
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881 71..90
Ion_trans 184..415 CDD:306908 5/15 (33%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 308..321
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375
DUF3399 445..546 CDD:314709
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881, ECO:0000305|PubMed:16934482 474..630
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..630
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881 627..630
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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