DRSC/TRiP Functional Genomics Resources

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Protein Alignment RpL37-2 and KCND2

DIOPT Version :10

Sequence 1:NP_611757.1 Gene:RpL37-2 / 37669 FlyBaseID:FBgn0034822 Length:89 Species:Drosophila melanogaster
Sequence 2:NP_036413.1 Gene:KCND2 / 3751 HGNCID:6238 Length:630 Species:Homo sapiens


Alignment Length:15 Identity:5/15 - (33%)
Similarity:10/15 - (66%) Gaps:0/15 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 CGNSSYHLQKSKCSQ 36
            ||:|..|:::..|.:
Human   209 CGSSPGHIKELPCGE 223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpL37-2NP_611757.1 PTZ00073 1..89 CDD:240257 5/15 (33%)
KCND2NP_036413.1 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
BTB_POZ 6..144 CDD:453885
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881 71..90
Ion_trans 184..415 CDD:459842 5/15 (33%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 308..321
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375
DUF3399 470..546 CDD:463381
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881, ECO:0000305|PubMed:16934482 474..630
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..630
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881 627..630
Blue background indicates that the domain is not in the aligned region.

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