DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9876 and ISX

DIOPT Version :9

Sequence 1:	NP_611756.1	Gene:	CG9876 / 37668	FlyBaseID:	FBgn0034821	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_001290437.1	Gene:	ISX / 91464	HGNCID:	28084	Length:	245	Species:	Homo sapiens

Alignment Length:	192	Identity:	64/192 - (33%)
Similarity:	84/192 - (43%)	Gaps:	42/192 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 FSVDNIMEMKHDAYSKGKMAMELSSNFGPTGAGCGGADRPAPCSGNLPAGGGHHSRK-PRRNRTT 123
            ||::.|  :|..|........|.....||..|...|:....|     |.......|| .||.|||
Human    31 FSIEAI--LKRPARRSDMDRPEGPGEEGPGEAAASGSGLEKP-----PKDQPQEGRKSKRRVRTT 88

  Fly   124 FSSAQLTALEKVFERTHYPDAFVREELATKVHLSEARVQVWFQNRRAKFRRNER----------- 177
            |::.||..|||:|..|||||..:|.:||.:::|.|||||:||||:|||:|:.|:
Human    89 FTTEQLHELEKIFHFTHYPDVHIRSQLAARINLPEARVQIWFQNQRAKWRKQEKIGNLGAPQQLS 153

  Fly   178 --SVGSRTLLDTA---------PQLVP----APISNNMHKYANMP--------HPHPQPPPP 216
              ||...|.||.|         .:|.|    .|.:.:....|..|        ||....|.|
Human   154 EASVALPTNLDVAGPTWTSTALRRLAPPTSCCPSAQDQLASAWFPAWITLLPAHPWETQPVP 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9876	NP_611756.1	Homeobox	121..173	CDD:278475	31/51 (61%)
ISX	NP_001290437.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..86		13/52 (25%)
ISX	NP_001290437.1	Homeobox	86..138	CDD:278475	31/51 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010