Protein Alignment CG9876 and SHOX

DIOPT Version :10

• Sequence 1: NP_611756.1
• Gene: CG9876 / 37668
• FlyBaseID: FBgn0034821
• Length: 275
• Species: Drosophila melanogaster
• Sequence 2: NP_000442.1
• Gene: SHOX / 6473
• HGNCID: 10853
• Length: 292
• Species: Homo sapiens
• Alignment Length: 241
• Identity: 76/241 - (31%)
• Similarity: 98/241 - (40%)
• Gaps: 80/241 - (33%)

  Fly    28 EIYSSHQSHNLE---SEDKLEDREESGRNLDKIHRFS--VDNIMEMKHDAYSKGKMAMELSSNFG 87
            |:..|..:.:.|   |:..|:|..|.|.:. .:|.|.  |||         .|.|:     ..||
Human    37 EVLESGLARSRELGTSDSSLQDITEGGGHC-PVHLFKDHVDN---------DKEKL-----KEFG 86

  Fly    88 PTGAGCG------------GADRPAPCSGNLPAGGGHHSRKPRRNRTTFSSAQLTALEKVFERTH 140
            ......|            ..|.           .|....|.||:||.|:..||..||::|:.||
Human    87 TARVAEGIYECKEKREDVKSEDE-----------DGQTKLKQRRSRTNFTLEQLNELERLFDETH 140

  Fly   141 YPDAFVREELATKVHLSEARVQVWFQNRRAKFRRNERSVGSRTLLDTAPQLVPAPISNNMHKYAN 205
            |||||:||||:.::.||||||||||||||||.|:.|..:....:|.||..|....::    .|.|
Human   141 YPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTANHLDACRVA----PYVN 201

  Fly   206 M-----------------------PHPHPQ----------PPPPPG 218
            |                       ||.||.          ||||.|
Human   202 MGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHAPYLMFPPPPFG 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9876	NP_611756.1	Homeodomain	118..174	CDD:459649	37/55 (67%)
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..119		3/29 (10%)
		Homeodomain	118..174	CDD:459649	37/55 (67%)
		SH3-binding. /evidence=ECO:0000255	242..249		5/6 (83%)
		OAR	272..288	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	274..287