DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9876 and ALX4

DIOPT Version :9

Sequence 1:	NP_611756.1	Gene:	CG9876 / 37668	FlyBaseID:	FBgn0034821	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_068745.2	Gene:	ALX4 / 60529	HGNCID:	450	Length:	411	Species:	Homo sapiens

Alignment Length:	227	Identity:	80/227 - (35%)
Similarity:	102/227 - (44%)	Gaps:	53/227 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SSNFGPTGAGCGG------ADRPAPCSGNLPAGGGHHSRKPRRNRTTFSSAQLTALEKVFERTHY 141
            ||......||..|      :|.|:|..   .|....:..|.|||||||:|.||..|||||::|||
Human   177 SSYLSVKEAGVKGPQDRASSDLPSPLE---KADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHY 238

  Fly   142 PDAFVREELATKVHLSEARVQVWFQNRRAKFRRNERSVGS----RTLLDTAPQLVPAPISNNMHK 202
            ||.:.||:||.:..|:||||||||||||||:|:.|| .|.    ||...||.:|   |:......
Human   239 PDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRER-FGQMQQVRTHFSTAYEL---PLLTRAEN 299

  Fly   203 YANMPHPH-------PQPPP------------------PPGAYALNFGPLELRSCQNYTNCYGGF 242
            ||.:.:|.       ..|.|                  |||:.|        .|..::.:..|..
Human   300 YAQIQNPSWLGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGA--------SSVTDFLSVSGAG 356

  Fly   243 GSSGASGSGVCSFFGATNYCVAAN-YAKNAYP 273
            ...|.:..|  |.|||.:.....| |..|..|
Human   357 SHVGQTHMG--SLFGAASLSPGLNGYELNGEP 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9876	NP_611756.1	Homeobox	121..173	CDD:278475	36/51 (71%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..145
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		11/37 (30%)
		Homeobox	218..270	CDD:278475	36/51 (71%)
		OAR	387..404	CDD:281777	80/227 (35%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	391..404
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010