DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9876 and PRRX1

DIOPT Version :9

Sequence 1:	NP_611756.1	Gene:	CG9876 / 37668	FlyBaseID:	FBgn0034821	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_073207.1	Gene:	PRRX1 / 5396	HGNCID:	9142	Length:	245	Species:	Homo sapiens

Alignment Length:	200	Identity:	86/200 - (43%)
Similarity:	114/200 - (56%)	Gaps:	31/200 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSHQSHNLESEDKLEDREESGRNLDKIH---RFSVDNIMEMKHDAYSKGKM-AMELSSNFGPTGA 91
            :|...|.||.:..|..|.:|..|||.:.   .|||.::::::    ..|.| |.:...|.|..|.
Human     2 TSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLE----EAGDMVAAQADENVGEAGR 62

  Fly    92 G-------CGGADRPAPCSGNLPAGGGHHSRKPRRNRTTFSSAQLTALEKVFERTHYPDAFVREE 149
            .       ..|:|.|...:..|.: .....||.|||||||:|:||.|||:||||||||||||||:
Human    63 SLLESPGLTSGSDTPQQDNDQLNS-EEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVRED 126

  Fly   150 LATKVHLSEARVQVWFQNRRAKFRRNERSV---GSRTLLDTAPQLVPA---PISNNMHKYANMPH 208
            ||.:|:|:||||||||||||||||||||::   .:.:||.:....|.|   ||         :|.
Human   127 LARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPI---------VPR 182

  Fly   209 PHPQP 213
            |.|:|
Human   183 PAPRP 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9876	NP_611756.1	Homeobox	121..173	CDD:278475	42/51 (82%)
PRRX1	NP_073207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..103		13/40 (33%)
		Homeobox	99..151	CDD:395001	42/51 (82%)
		OAR	219..235	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	222..235
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154128
Domainoid	1	1.000	105	1.000	Domainoid score	I6658
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4715
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		otm41492
orthoMCL	1	0.900	-	-		OOG6_114029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5800
SonicParanoid	1	1.000	-	-		X3194
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.780