DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9876 and PAX3

DIOPT Version :10

Sequence 1:NP_611756.1 Gene:CG9876 / 37668 FlyBaseID:FBgn0034821 Length:275 Species:Drosophila melanogaster
Sequence 2:NP_852124.1 Gene:PAX3 / 5077 HGNCID:8617 Length:505 Species:Homo sapiens


Alignment Length:280 Identity:83/280 - (29%)
Similarity:114/280 - (40%) Gaps:89/280 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 NPGNFYYG----------------PTVS--GEIYSSHQSHNLESEDKLE--DREESGRNLDKIHR 59
            |||.|.:.                |:||  ..|..|......|.|..||  :.|||    :|..:
Human   125 NPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEES----EKKAK 185

  Fly    60 FSVDNIMEMKHDAYSKGKMAMELSSNFGPTGAGCGGADRPAPCSGNLPAGGGHHSRKPRRNRTTF 124
            .|:|.|:..:..|....:                 |:|  .....:||.     .||.||:||||
Human   186 HSIDGILSERASAPQSDE-----------------GSD--IDSEPDLPL-----KRKQRRSRTTF 226

  Fly   125 SSAQLTALEKVFERTHYPDAFVREELATKVHLSEARVQVWFQNRRAKFRRNERSVGSRTLL---- 185
            ::.||..||:.||||||||.:.|||||.:..|:||||||||.||||::|   :..|:..|:    
Human   227 TAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWR---KQAGANQLMAFNH 288

  Fly   186 -------DTA-PQLVPAPISNNMHKYANMPHP---------HPQPPPP--------------PGA 219
                   .|| |.|....:|...::..::|..         .|||.||              ..|
Human   289 LIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSA 353

  Fly   220 YALNFGPLELRSCQNYTNCY 239
            |.|   |.......:||:.:
Human   354 YCL---PSTRHGFSSYTDSF 370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9876NP_611756.1 Homeodomain 118..174 CDD:459649 36/55 (65%)
PAX3NP_852124.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
PAX 34..159 CDD:128645 8/33 (24%)
PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 37..93
RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 113..161 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 165..228 24/90 (27%)
Homeodomain 220..276 CDD:459649 37/58 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 309..351 6/41 (15%)
Pax7 347..391 CDD:403540 6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

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