DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9876 and ARX

DIOPT Version :9

Sequence 1:	NP_611756.1	Gene:	CG9876 / 37668	FlyBaseID:	FBgn0034821	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_620689.1	Gene:	ARX / 170302	HGNCID:	18060	Length:	562	Species:	Homo sapiens

Alignment Length:	297	Identity:	88/297 - (29%)
Similarity:	121/297 - (40%)	Gaps:	89/297 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GNPGNFYYGPTVSGEIYSSHQSHNLESEDKLEDREESGRNLDKIHRFSVDNIMEMKHDAYSKGKM 78
            |.||:   .|...|...:......|..:::.||.||.....|:      :.::|....|..|...
Human   209 GGPGS---APAAGGGTGTEDDEEELLEDEEDEDEEEELLEDDE------EELLEDDARALLKEPR 264

  Fly    79 AMELSSNFGPTGAGCGGADRPAPCSGN-------------------------LPAGG----GHHS 114
            ...:::    |||....|.......|.                         |.||.    |...
Human   265 RCPVAA----TGAVAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLK 325

  Fly   115 RKPRRNRTTFSSAQLTALEKVFERTHYPDAFVREELATKVHLSEARVQVWFQNRRAKFRRNERSV 179
            ||.||.||||:|.||..||:.|::|||||.|.|||||.::.|:||||||||||||||:|:.|::
Human   326 RKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA- 389

  Fly   180 GSRTLLDTAPQLVPAPIS--NNMHKYANM----PH-----------------PHPQPPPPPGAYA 221
            |::|.....|  .|.|:|  :.:..|.:.    ||                 ..|..|||||:.:
Human   390 GAQTHPPGLP--FPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSAS 452

  Fly   222 LNFGPLELRSCQNYTNCYGGFGSSGASGSGVCSFFGA 258
            |                    ..|||. .|:.:|.||
Human   453 L--------------------PPSGAP-LGLSTFLGA 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9876	NP_611756.1	Homeobox	121..173	CDD:278475	36/51 (71%)
ARX	NP_620689.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..81
		GCG-encoded polyalanine repeat	102..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..255		12/54 (22%)
		Homeobox	332..385	CDD:395001	36/52 (69%)
		OAR	526..544	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	530..543
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010