Protein Alignment CG9876 and DMBX1

DIOPT Version :10

• Sequence 1: NP_611756.1
• Gene: CG9876 / 37668
• FlyBaseID: FBgn0034821
• Length: 275
• Species: Drosophila melanogaster
• Sequence 2: NP_671725.1
• Gene: DMBX1 / 127343
• HGNCID: 19026
• Length: 382
• Species: Homo sapiens
• Alignment Length: 166
• Identity: 60/166 - (36%)
• Similarity: 85/166 - (51%)
• Gaps: 17/166 - (10%)

  Fly    64 NIMEMKHDAYSKGKMAMELSSNFGPTGAGCGGADRPAPCSGN---LPAGGGHHSRKPRRNRTTFS 125
            |.:...::.:.:.....:.:.::.|:......|:|.|.|:..   |.|..|...||.||:||.|:
Human    15 NSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRRSRTAFT 79

  Fly   126 SAQLTALEKVFERTHYPDAFVREELATKVHLSEARVQVWFQNRRAKFRRNERSVGSRTLLDTAPQ 190
            :.||.||||.|::|||||..:||.||...:|.||||||||:|||||||:.:||:...       |
Human    80 AQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKE-------Q 137

  Fly   191 LVPAPISNNMHKYANMPHPHP-------QPPPPPGA 219
            |.....:...|.......|.|       |||..||:
Human   138 LQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGS 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9876	NP_611756.1	Homeodomain	118..174	CDD:459649	36/55 (65%)
DMBX1	NP_671725.1	Interaction with OTX2 and is required for repressor activity. /evidence=ECO:0000250|UniProtKB:Q91ZK4	1..156		53/147 (36%)
		Homeodomain	72..128	CDD:459649	36/55 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..252		12/53 (23%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	359..372