Protein Alignment Art7 and PRMT9

DIOPT Version :9

• Sequence 1: NP_611753.4
• Gene: Art7 / 37664
• FlyBaseID: FBgn0034817
• Length: 690
• Species: Drosophila melanogaster
• Sequence 2: NP_612373.2
• Gene: PRMT9 / 90826
• HGNCID: 25099
• Length: 845
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 162/688 - (23%)
• Similarity: 260/688 - (37%)
• Gaps: 220/688 - (31%)

  Fly    38 MLHDWERNQKYFAALRKTIA-GMREAGREVHVLDIGTGTGILSMMALAAGADSVTACEAFLPMAN 101
            ||:|.:||..|.||::|.:. |.:.      |||||.|||||||.|..|||.||.|||....|..
Human   156 MLNDTKRNTIYNAAIQKAVCLGSKS------VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYE 214

  Fly   102 CAEKILAANGAGDKVRLIRKRSTEIQVGEDMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLT 166
            .|..::|||.....::|:..:|.:|::.:.:|.:.:|:|.|.:|..|.|||.:....||...||.
Human   215 LACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLL 279

  Fly   167 ------EDALC------IPARARCYAQVAQSPLAAQWN--SLKTIANLDGEPLLHPPEQLK---- 213
                  |.|.|      |||.|..:....:.....:.:  .:|.||.      :|.|..:|
Human   280 QPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAG------IHLPTNVKFQSP 338

  Fly   214 ---SCQGEAALHDV---QLSQLPSSAFRPLTDPVEIFQFDFQRKQEREKQRSQLLKLQSKQP--- 269
               |...|..:...   ::|::| ..:..||:..||...||...||       |..|.:|:|
Human   339 AYSSVDTEETIEPYTTEKMSRVP-GGYLALTECFEIMTVDFNNLQE-------LKSLATKKPDKI 395

  Fly   270 -------GAAELVFYWWDIQLDDDGEILLS-----C-----------APYWAHPQLKELAAEKAK 311
                   |..:.:..|:.:||||:..:..|     |           |.||..|          .
Human   396 GIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLADYWIKP----------G 450

  Fly   312 DHPLPNVVPWRDHWM--QAIYYIPKPLQLLEAGKSFHLSCHHDEYSLWFDAR--------EEAPT 366
            ||.:.. |..:|.::  |:|..:....: ::..|||  :.:.|..||..:|.        :.:..
Human   451 DHVMME-VSCQDCYLRIQSISVLGLECE-MDVAKSF--TQNKDLLSLGNEAELCSALANLQTSKP 511

  Fly   367 KSVRRHTCTCDLHMTYSRSRIGQLNQSPRNKRYLRYLEE---SIEAEK---------SNVLVLGN 419
            .:|.:   ||.|..|    .|..||..|.::.:...:.:   |:..||         .|.:..|.
Human   512 DAVEQ---TCILEST----EIALLNNIPYHEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGT 569

  Fly   420 G---------------------CLLGLASSALGA----ASV----------LLHEPHRFSRRLIE 449
            |                     .:|.:.:..||.    :||          |:.|.:.|.:..:|
Human   570 GQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLISEANHFPKETLE 634

  Fly   450 SIVKH-------------NQLKNVQFLDKVE-----ELEDSRLAALTHIFAEPYFLNAILPWDNF 496
            ..::|             ::|.::..||.:|     :.|....||::....:..  ..|.|....
Human   635 FWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSG--GKIFPQYVL 697

  Fly   497 YFGTLLTKIKDRLPE----------GVKISPCSARIYALPVE-FLDLHKIRAPVGSCEGFDLRLF 550
            .|| ||.:.:..|.|          |:.|:|...: :.:|:. ||||..:
Human   698 MFG-LLVESQTLLEENAVQGTERTLGLNIAPFINQ-FQVPIRVFLDLSSL--------------- 745

  Fly   551 DEMVERSAEQAVSLVEAQPLWEYPCRALSEPQEVLSVD 588
                                   ||..||:|.|:|.:|
Human   746 -----------------------PCIPLSKPVELLRLD 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Art7	NP_611753.4	AdoMet_MTases	36..>186	CDD:302624	59/160 (37%)
PRMT9	NP_612373.2	TPR 1	25..58
		TPR	<39..144	CDD:223533
		TPR 2	67..100
		TPR repeat	68..95	CDD:276809
		TPR repeat	100..130	CDD:276809
		TPR 3	101..134
		AdoMet_MTases	148..>303	CDD:327401	59/152 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810