DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art7 and PRMT6

DIOPT Version :9

Sequence 1:	NP_611753.4	Gene:	Art7 / 37664	FlyBaseID:	FBgn0034817	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_060607.2	Gene:	PRMT6 / 55170	HGNCID:	18241	Length:	375	Species:	Homo sapiens

Alignment Length:	357	Identity:	75/357 - (21%)
Similarity:	125/357 - (35%)	Gaps:	139/357 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DMLHDWERNQKYFAALRKTIAGMREAGREVHVLDIGTGTGILSMMALAAGADSVTACEAFLPMAN 101
            :|:.|..|...|...:.:..|.:|  |:.  |||:|.||||||:....|||..|.|.|| ..:..
Human    59 EMIADRVRTDAYRLGILRNWAALR--GKT--VLDVGAGTGILSIFCAQAGARRVYAVEA-SAIWQ 118

  Fly   102 CAEKILAANGAGDKVRLIRKRSTEIQVGEDMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLT 166
            .|.:::..||..|:|.::......:    ::|.:.:.:|:|.:...|:.|..:....||..:.|.
Human   119 QAREVVRFNGLEDRVHVLPGPVETV----ELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLK 179

  Fly   167 EDALCIPARARCYAQVAQSPLAAQ--------WNSLK------------------------TIAN 199
            |..|.:||.|..:.    :|::.|        |:.:|                        .:..
Human   180 EGGLLLPASAELFI----APISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQG 240

  Fly   200 LDGEPLLHPPE---QLK--------------------SCQGEAALHDVQLSQLPSSAFRPLTDPV 241
            |.||.:|..|:   ||:                    ||.|.|.:|...:
Human   241 LSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAI--------------- 290

  Fly   242 EIFQFDFQRKQEREKQRSQLLKLQSKQPGAAELVFYWWDIQLDDDGEILLSCAPYWAHPQLKELA 306
             .||..|                    ||.            :.:..::||.:|:
Human   291 -WFQVTF--------------------PGG------------ESEKPLVLSTSPF---------- 312

  Fly   307 AEKAKDHPLPNVVPWRDHWMQAIYYIPKPLQL 338
                  ||       ..||.||:.|:.:|:|:
Human   313 ------HP-------ATHWKQALLYLNEPVQV 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art7	NP_611753.4	AdoMet_MTases	36..>186	CDD:302624	42/148 (28%)
PRMT6	NP_060607.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
PRMT6	NP_060607.2	AdoMet_MTases	67..>200	CDD:418430	40/145 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810