Protein Alignment Art7 and PRMT7

DIOPT Version :10

• Sequence 1: NP_611753.4
• Gene: Art7 / 37664
• FlyBaseID: FBgn0034817
• Length: 690
• Species: Drosophila melanogaster
• Sequence 2: XP_011521414.1
• Gene: PRMT7 / 54496
• HGNCID: 25557
• Length: 714
• Species: Homo sapiens
• Alignment Length: 717
• Identity: 255/717 - (35%)
• Similarity: 389/717 - (54%)
• Gaps: 63/717 - (8%)

  Fly     1 MSCFSHVMNPITGQNSWQERGDDYDYHLEVANAGFGDMLHDWERNQKYFAALRKTIAGMREAGRE 65
            |..|....||.||...|.|..:.||||.|:|.:.:.|||||.:||.||:..:|..::.:::.|::
Human     1 MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQK 65

  Fly    66 VHVLDIGTGTGILSMMALAAGADSVTACEAFLPMANCAEKILAANGAGDKVRLIRKRSTEIQVGE 130
            ..|||||||||:|||||:.||||...|.|.|.|||:.|.||:..||..||:::|.|.|||:.||.
Human    66 ALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGP 130

  Fly   131 --DMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLTEDALCIPARARCYAQVAQSPLAAQWNS 193
              |||.:||:||.||.|||||||||:..|.|||..|:.|:...:|.||..|||:.:|.....||.
Human   131 EGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNK 195

  Fly   194 LKTI---ANLDGEPLLHPPEQLKSCQGEAALHDVQLSQLPSSAFRPLTDPVEIFQFDFQRKQERE 255
            |..|   .:| ||.::.||..::||.|..::.|:||:|:..:.|..|:|.:.:|..||. ||...
Human   196 LFPIHVQTSL-GEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFS-KQVSS 258

  Fly   256 KQRSQLLKLQSKQPGAAELVFYWWDIQLDDDGEILLSCAPYWAHPQLKELAAEKAKDHPLPNVVP 320
            .......:.:....|.|::|..||||::|.:|:|..:.||:|||..              |..:.
Human   259 SAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSD--------------PEEMQ 309

  Fly   321 WRDHWMQAIYYIPKPLQLLEAGKSFHLSCHHDEYSLWFDAREEAPTKSVR----RHTCTCDLHMT 381
            |||||||.:|::|:...::: |.:.:|..|||:|.:|:..:..:|.|:.|    |..|.|..|:.
Human   310 WRDHWMQCVYFLPQEEPVVQ-GSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLL 373

  Fly   382 YSRSRIGQLNQSPRNKRYLRYLEESIEAEKSNVLVLGNGCLLGLASSALGAASVLLHEPHRFSRR 446
            ::|.|.|::|...|..||::.|...::.: |..|.:.:|.||.:.:..||...|...|....|.:
Human   374 WNRPRFGEINDQDRTDRYVQALRTVLKPD-SVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHK 437

  Fly   447 LIESIVKHNQLKN-VQFLDKVEEL---EDSRLAALTHIFAEPYFLNAILPWDNFYF------GTL 501
            |:..|.|.|.|:: :..::|..||   ||.:...::.:..||:|..::|||.|.||      ...
Human   438 LLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWCAGNSKMC 502

  Fly   502 LTKIKDRLP----EGVKISPCSARIYALPVEFLDLHKIRAPVGSCEGFDLRLFDEMVERSAEQAV 562
            |..:..|.|    .||..:..|::         ||.:||:|.|.|||||:.:.|:|::|:.:...
Human   503 LLFLLPRFPVSWRAGVDGAAPSSQ---------DLWRIRSPCGDCEGFDVHIMDDMIKRALDFRE 558

  Fly   563 SL-VEAQPLWEYPCRALSEPQEVLSVDFSNFG--QEHSLKGSIELKHPRICNGVALWVDWQLVED 624
            |. .|..||||||||:||||.::|:.||....  |....:|::||:.|...:...||:::.|
Human   559 SREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHL--- 620

  Fly   625 NSPRSIVSSGPSEPVVPGEFVKWDMFVRQGVHF------PRRPKEAITHLEWSTVFKPLLGELTF 683
             :|...:|:|..||..|.....|:...:|.|:|      ||........:.::..|.|..|::..
Human   621 -TPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDIIM 684

  Fly   684 SF 685
            .|
Human   685 EF 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Art7	NP_611753.4	COG4076	38..>189	CDD:443253	79/152 (52%)
PRMT7	XP_011521414.1	COG4076	38..>187	CDD:443253	78/148 (53%)
		COG4076	382..>457	CDD:443253	20/75 (27%)