DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art7 and Prmt8

DIOPT Version :9

Sequence 1:	NP_611753.4	Gene:	Art7 / 37664	FlyBaseID:	FBgn0034817	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_958759.2	Gene:	Prmt8 / 381813	MGIID:	3043083	Length:	394	Species:	Mus musculus

Alignment Length:	420	Identity:	90/420 - (21%)
Similarity:	158/420 - (37%)	Gaps:	104/420 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SC-----FSHVMNPITGQNSWQERGDDYDYHLEVANAGFG---DMLHDWERNQKYFAALRKTIAG 58
            ||     .|.::||        |.....||:.: :.|.||   :||.|..|...|    |.::..
Mouse    54 SCPGRGKMSKLLNP--------EEMTSRDYYFD-SYAHFGIHEEMLKDEVRTLTY----RNSMYH 105

  Fly    59 MREAGREVHVLDIGTGTGILSMMALAAGADSVTACEAFLPMANCAEKILAANGAGDKVRLIRKRS 123
            .:...::..|||:|:|||||||.|..|||..|...|. ..:::.:|||:.||...:.:.:.:.:.
Mouse   106 NKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIEC-SSISDYSEKIIKANHLDNVITIFKGKV 169

  Fly   124 TEIQVGEDMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLTEDALCIPARARCYAQVAQSPLA 188
            .|:::..:   |.:::::|.:...|..|..:.....|..:.|....|..|.||..|....:.
Mouse   170 EEVELPVE---KVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIED--- 228

  Fly   189 AQWNSLKTIANLDGEPLLHPPEQL----KSCQGEAALHDVQLSQLPSSAFRPLTDPVE------- 242
            .|:...|          :|..|.:    .:|     :.||.:.:       ||.|.|:
Mouse   229 RQYKDFK----------IHWWENVYGFDMTC-----IRDVAMKE-------PLVDIVDPKQVVTN 271

  Fly   243 ---IFQFDFQRKQEREKQRSQLLKLQSKQPGAAELVFYWWDIQLDDDGEILLSCAPYWAHPQLKE 304
               |.:.|....:..|...:....||.::......:..:::|:       ...|     |   |:
Mouse   272 ACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIE-------FTKC-----H---KK 321

  Fly   305 LAAEKAKDHPLPNVVPWRDHWMQAIYYIPKPLQLLEAGKSFHLSCHHDEYSLWFDAREEAPTKSV 369
            :....|.|.|.       .||.|.::|:..           :|:....| .::.....:...|:|
Mouse   322 MGFSTAPDAPY-------THWKQTVFYLED-----------YLTVRRGE-EIYGTISMKPNAKNV 367

  Fly   370 RRHTCTCDLHMTYSRSRIGQLNQSPRNKRY 399
            |      ||..|......|||.::..:..|
Mouse   368 R------DLDFTVDLDFKGQLCETSVSNDY 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art7	NP_611753.4	AdoMet_MTases	36..>186	CDD:302624	41/152 (27%)
Prmt8	NP_958759.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..40
		SH3-binding 1. /evidence=ECO:0000250\|UniProtKB:Q9NR22	29..42
		SH3-binding 2. /evidence=ECO:0000250\|UniProtKB:Q9NR22	53..58		2/3 (67%)
		AdoMet_MTases	115..215	CDD:100107	30/103 (29%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q9NR22	119..122		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810