DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art7 and Carm1

DIOPT Version :9

Sequence 1:	NP_611753.4	Gene:	Art7 / 37664	FlyBaseID:	FBgn0034817	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_001025212.1	Gene:	Carm1 / 363026	RGDID:	1305879	Length:	608	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	107/479 - (22%)
Similarity:	172/479 - (35%)	Gaps:	119/479 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SCFSHVMNPITGQNSWQERGDD---------YDYHLEVANAGFGDMLHDWERNQKYFAALRKTIA 57
            :|..|.:.    ::.:.||.::         |.|..:..|     |:.|:.|...|..|:.:...
  Rat   127 TCRGHTLE----RSVFSERTEESSAVQYFQFYGYLSQQQN-----MMQDYVRTGTYQRAILQNHT 182

  Fly    58 GMREAGREVHVLDIGTGTGILSMMALAAGADSVTACEAFLPMANCAEKILAANGAGDKVRLIRKR 122
            ..::.    .|||:|.|:||||..|..|||..:.|.|| ..||..||.::.:|...|::.:|..:
  Rat   183 DFKDK----IVLDVGCGSGILSFFAAQAGARKIYAVEA-STMAQHAEVLVKSNNLTDRIVVIPGK 242

  Fly   123 STEIQVGEDMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLTEDALCIPARARCYAQVAQSPL 187
            ..|:    .:|.:.:::::|.:...|..|..:..|.|                       |:..|
  Rat   243 VEEV----SLPEQVDIIISEPMGYMLFNERMLESYLH-----------------------AKKYL 280

  Fly   188 AAQWNSLKTIANLDGEPLLHPPEQLKSCQ-------GEAALHDVQLSQLPSSA----FR-PLTDP 240
            ....|...||.::...|.  ..|||...|       .:.:.|.|.||.|..:|    || |:.|.
  Rat   281 KPSGNMFPTIGDVHLAPF--TDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDT 343

  Fly   241 VEI---------FQFDFQRKQEREKQRSQL-LKLQSKQPGAAELVFYWWDIQLDDDGEIL---LS 292
            .:|         :..:|...:|.:..|.:: .|......|....:.:|:|:..  .|.|:   ||
  Rat   344 FDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAF--IGSIMTVWLS 406

  Fly   293 CAPYWAHPQLKELAAEKAKDHPLPNVVPWRDHWMQAIYYIPKPLQLLEAGKSFHLSC-----HHD 352
            .||                ..||       .||.|.......|| ..:||.:...:|     ...
  Rat   407 TAP----------------TEPL-------THWYQVRCLFQSPL-FAKAGDTLSGTCLLIANKRQ 447

  Fly   353 EYSLWFDAR-EEAPTKSVRRHTCTCDLHMTYSRSRIGQLNQSPRNKRYLRYLEE-----SIEAEK 411
            .|.:...|: ::..:||    :...||...:.| ..|.....|....|....|.     |.....
  Rat   448 SYDISIVAQVDQTGSKS----SNLLDLKNPFFR-YTGTTPSPPPGSHYTSPSENMWNTGSTYNLS 507

  Fly   412 SNVLVLGNGCLLGLASSALGAASV 435
            |.|.|.|......|:|...|.:||
  Rat   508 SGVAVAGMPTAYDLSSVIAGGSSV 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art7	NP_611753.4	AdoMet_MTases	36..>186	CDD:302624	36/149 (24%)
Carm1	NP_001025212.1	CARM1	35..139	CDD:402914	2/15 (13%)
Carm1	NP_001025212.1	AdoMet_MTases	189..284	CDD:100107	32/122 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810