DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art7 and Prmt9

DIOPT Version :9

Sequence 1:	NP_611753.4	Gene:	Art7 / 37664	FlyBaseID:	FBgn0034817	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_001178528.1	Gene:	Prmt9 / 291947	RGDID:	1306157	Length:	841	Species:	Rattus norvegicus

Alignment Length:	722	Identity:	172/722 - (23%)
Similarity:	274/722 - (37%)	Gaps:	184/722 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MLHDWERNQKYFAALRKTIAGMREAGREVHVLDIGTGTGILSMMALAAGADSVTACEAFLPMANC 102
            ||:|.:||:.|.||::|.:    ..|.:. |||||.|||||||.|..|||.||.|||....|...
  Rat   156 MLNDTKRNEIYNAAIQKAV----RLGSKT-VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYEL 215

  Fly   103 AEKILAANGAGDKVRLIRKRSTEIQVGEDMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLTE 167
            |..::|||...|.:||:..:|.::::.:.:|.:.:|:|.|.:|..:.|||.:....||...||.:
  Rat   216 ACDVVAANKMEDGIRLLHMKSLDLEIPKHIPERVSLVVTETVDAGVFGEGIVESLIHAWEHLLLQ 280

  Fly   168 D------------ALCIPARA------------RCYAQVAQSPLA-------AQWNSLKTIANLD 201
            .            ...|||.|            |.:.:|:...:|       .::.| ...|::|
  Rat   281 PQTKGESGSWGKYGKVIPASAVISGMAVECAEIRRHHRVSAKDIAGIHLPTNVRFQS-PAYASVD 344

  Fly   202 GEPLLHPPEQLKSCQGEAALHDVQLSQLPSSAFRPLTDPVEIFQFDFQRKQEREK---QRSQLLK 263
            .|..:.|....|            :|.:| ..:||||:..:|.:.||...||.:.   ::...|.
  Rat   345 PEETVEPYTTEK------------MSGIP-GGYRPLTECFQIMKVDFNNLQELKSLATRKPHSLS 396

  Fly   264 LQSKQPGAAELVFYWWDIQLDDDGEILLSCAP------------------YWAHPQLKELAAEKA 310
            :.:.:.|..:.:..|:.:||||  |..||.:|                  ||..|  .:....:|
  Rat   397 VPAVKEGTLDAIMVWFVLQLDD--EHSLSTSPSEETCWEQAVYPVQALEDYWIQP--GDQVTMEA 457

  Fly   311 KDHP----LPNV-VPWRDHWMQAIYYIPKPLQLLEAGKSFHLSCHHDEYSLWFDAREEAPTKSVR 370
            ..|.    :..: :...:|.|:.|....|...||..|....| |         .|.....|....
  Rat   458 SCHDCYLRIQGISILHLEHEMEVIKSFTKSKDLLSLGNEAEL-C---------SALANLQTSRPE 512

  Fly   371 RHTCTCDLHMTYSRSRIGQLNQSPRN-----------------------KRYLRYLEESIEAEKS 412
            ....||.|..|    .|..||..|.:                       :.:.:.:|.::|:..|
  Rat   513 ALEQTCVLEPT----EIALLNNIPYHEGFRTAMRKVLSSLAPETPSQPMEAHCQDMETNLESAPS 573

  Fly   413 N-----VLVLGNG-CLLGLASSALGA----ASV----------LLHEPHRFSRRLIESIVKHNQL 457
            .     ||.:..| .||.:.:..||.    :||          |:.|.:.|.:..:|..::|.:
  Rat   574 TSDPFYVLDVSEGFSLLPILAGTLGQVQPYSSVEKDQHCIALDLISEANHFPKETLEFWLRHIE- 637

  Fly   458 KNVQFLDKVEELEDSRLAALTHIFAEPYFLNAILPWDNFYFGTLLTKIKDR-------LPEGVKI 515
                  |:...|:..:...|..|.    .|:.|.|     .|.:..:|.::       |..|.||
  Rat   638 ------DEAAVLQRPKSDKLWSII----ILDVIEP-----SGLIQQEIMEKAAISRCLLQSGGKI 687

  Fly   516 SPCSARIYALPVEFLDLHKIRAPVGSCEGFDLRLFDEMVERSAEQAVSLVEAQPLWEYPCRALSE 580
            .|....::.:.||...|.:..|..|:.....|.:...:.:......|.|    .|...||..||:
  Rat   688 FPQYVLMFGMLVESQTLVEESAVQGTEHTLGLNIAPFINQFQVPIRVCL----DLSSLPCIPLSQ 748

  Fly   581 PQEVLSVDFSNFGQEHSLKGSIELKHPRIC-----NGVALWVDWQLVEDNSPRSIVSSGPSEPVV 640
            |.|:|.:|...   .:....:.|:| .|:|     ..|..|  :.|..|:..|...|
  Rat   749 PVELLRLDLMT---PYLNTSNREVK-VRVCRSGRLTAVPFW--FHLCLDDEVRLDTS-------- 799

  Fly   641 PGEFVKW 647
             ||...|
  Rat   800 -GEASHW 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art7	NP_611753.4	AdoMet_MTases	36..>186	CDD:302624	58/171 (34%)
Prmt9	NP_001178528.1	TPR_11	68..132	CDD:290150
		TPR repeat	68..95	CDD:276809
		TPR repeat	100..130	CDD:276809
		AdoMet_MTases	148..>338	CDD:302624	60/187 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810