DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art7 and CARM1

DIOPT Version :9

Sequence 1:	NP_611753.4	Gene:	Art7 / 37664	FlyBaseID:	FBgn0034817	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_954592.1	Gene:	CARM1 / 10498	HGNCID:	23393	Length:	608	Species:	Homo sapiens

Alignment Length:	452	Identity:	95/452 - (21%)
Similarity:	160/452 - (35%)	Gaps:	140/452 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SCFSHVMNPITGQNSWQERGDD---------YDYHLEVANAGFGDMLHDWERNQKYFAALRKTIA 57
            :|..|.:.    ::.:.||.::         |.|..:..|     |:.|:.|...|..|:.:...
Human   126 TCRGHTLE----RSVFSERTEESSAVQYFQFYGYLSQQQN-----MMQDYVRTGTYQRAILQNHT 181

  Fly    58 GMREAGREVHVLDIGTGTGILSMMALAAGADSVTACEAFLPMANCAEKILAANGAGDKVRLIRKR 122
            ..::.    .|||:|.|:||||..|..|||..:.|.|| ..||..||.::.:|...|::.:|..:
Human   182 DFKDK----IVLDVGCGSGILSFFAAQAGARKIYAVEA-STMAQHAEVLVKSNNLTDRIVVIPGK 241

  Fly   123 STEIQVGEDMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLTEDALCIPARARCYAQVAQSPL 187
            ..|:    .:|.:.:::::|.:...|..|..:..|.|                       |:..|
Human   242 VEEV----SLPEQVDIIISEPMGYMLFNERMLESYLH-----------------------AKKYL 279

  Fly   188 AAQWNSLKTIANLDGEPLLHPPEQLKSCQ-------GEAALHDVQLSQLPSSA----FR-PLTDP 240
            ....|...||.::...|.  ..|||...|       .:.:.|.|.||.|..:|    || |:.|.
Human   280 KPSGNMFPTIGDVHLAPF--TDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDT 342

  Fly   241 VEI---------FQFDFQRKQEREKQRSQL-LKLQSKQPGAAELVFYWWDIQLDDDGEIL---LS 292
            .:|         :..:|...:|.:..|.:: .|......|....:.:|:|:..  .|.|:   ||
Human   343 FDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAF--IGSIMTVWLS 405

  Fly   293 CAPYWAHPQLKELAAEKAKDHPLPNVVPWRDHWMQAIYYIPKPLQLLEAGKSFHLSCHHDEYSLW 357
            .||                ..||       .||.|.......|| ..:||.:...:|
Human   406 TAP----------------TEPL-------THWYQVRCLFQSPL-FAKAGDTLSGTC-------- 438

  Fly   358 FDAREEAPTKSVRRHTCTCDLHMTYSRSRIGQLNQSPRNKRYLRYLEESIEAEKSNVLVLGN 419
                           ....:...:|..|.:.|::|:              .::.||:|.|.|
Human   439 ---------------LLIANKRQSYDISIVAQVDQT--------------GSKSSNLLDLKN 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art7	NP_611753.4	AdoMet_MTases	36..>186	CDD:302624	36/149 (24%)
CARM1	NP_954592.1	CARM1	34..138	CDD:288395	2/15 (13%)
		PRMT5	<172..435	CDD:282971	75/322 (23%)
		Methyltransf_18	184..283	CDD:289607	32/130 (25%)
		Transactivation domain. /evidence=ECO:0000250	499..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810