DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art7 and PRMT3

DIOPT Version :9

Sequence 1:	NP_611753.4	Gene:	Art7 / 37664	FlyBaseID:	FBgn0034817	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_005779.1	Gene:	PRMT3 / 10196	HGNCID:	30163	Length:	531	Species:	Homo sapiens

Alignment Length:	352	Identity:	69/352 - (19%)
Similarity:	130/352 - (36%)	Gaps:	63/352 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DMLHDWERNQKYFAALRKTIAGMREAGREVHVLDIGTGTGILSMMALAAGADSVTACEAFLPMAN 101
            :||.|..|.:.|    |..|.......::..|||:|.|||||||.|..|||..|...:. ..:..
Human   232 EMLKDKIRTESY----RDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQ-SEILY 291

  Fly   102 CAEKILAANGAGDKVRLIRKRSTEIQVGEDMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLT 166
            .|..|:..|...|.:.||:.:..|:.:..:   |.:::::|.:...|:.|..:....:|..:.|.
Human   292 QAMDIIRLNKLEDTITLIKGKIEEVHLPVE---KVDVIISEWMGYFLLFESMLDSVLYAKNKYLA 353

  Fly   167 EDALCIPARARCYAQVAQSPL------AAQWNSLKTIANLDGEPLLHPPEQLKSCQGEAALHDVQ 225
            :.....|... ..:.||.|.:      .|.|:.:....              .||..:|.:.:..
Human   354 KGGSVYPDIC-TISLVAVSDVNKHADRIAFWDDVYGFK--------------MSCMKKAVIPEAV 403

  Fly   226 LSQLPSSAFRPLTDPVEIFQFDFQRKQEREKQRSQLLKLQSKQPGAAELVFYWWDIQLDDD--GE 288
            :..|.....  :::|..|...|.......:.:.|....|:..:......:..::||..:.:  ..
Human   404 VEVLDPKTL--ISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNR 466

  Fly   289 ILLSCAPYWAHPQLKELAAEKAKDHPLPNVVPWRDHWMQAIYYIPKPLQLLEAGKSF--HLSCHH 351
            ::.|..|.                       ..:.||.|.::.:.||.. ::||::.  .::.|.
Human   467 VVFSTGPQ-----------------------STKTHWKQTVFLLEKPFS-VKAGEALKGKVTVHK 507

  Fly   352 DEYSLWFDAREEAPTKSVRRHTCTCDL 378
            ::.    |.|....|.::...|.|..|
Human   508 NKK----DPRSLTVTLTLNNSTQTYGL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art7	NP_611753.4	AdoMet_MTases	36..>186	CDD:302624	39/148 (26%)
PRMT3	NP_005779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
PRMT3	NP_005779.1	AdoMet_MTases	259..359	CDD:100107	29/103 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810