Protein Alignment KCNJ10 and Irk2

DIOPT Version :9

• Sequence 1: NP_002232.2
• Gene: KCNJ10 / 3766
• HGNCID: 6256
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Alignment Length: 351
• Identity: 136/351 - (38%)
• Similarity: 196/351 - (55%)
• Gaps: 20/351 - (5%)

Human    27 RRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAV 91
            |||.:.|:|..||..:|:..:|..:|:|::||.:|.|||:.||.|:.:|..:|..|.::|:|:..
  Fly    96 RRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIY 160

Human    92 AHGDLLELDPPANH-----TPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQL 151
            .||||.|...|.|.     .|||..:...|..||||:|:|.|||||.|..|.|||.||.::..|.
  Fly   161 THGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQS 225

Human   152 VLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGK 216
            :...:...|:.|...||:.|.|:||:|:.||:|||:...:|...||.||.:||||.:||..|..:
  Fly   226 IYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQ 290

Human   217 LLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGD-FELV 280
            |::|..|||||.:......:....|.:....|.|.|:...|.:||.|||.:|.......| ||:|
  Fly   291 LIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIV 355

Human   281 LILSGTVESTSATCQVRTSYLPEEILWGYEFTPAI----SLSASGKYIADFSLFDQVVKVASP-S 340
            :||.||||||..:.|.|:||:..|||||:.|.|.:    .|.|   |..|::.|::..:|.:| .
  Fly   356 VILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQA---YEIDYARFNETTQVDTPLC 417

Human   341 GLRDSTVRYGDPEKLKLEESLREQAE 366
            ..|:....|      |::|..|..||
  Fly   418 SARELNEIY------KIQEGFRTPAE 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNJ10	NP_002232.2	IRK	31..172	CDD:395797	56/145 (39%)
		Selectivity filter. /evidence=ECO:0000250	128..133		4/4 (100%)
		IRK_C	179..354	CDD:407551	67/180 (37%)
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	130/342 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.030