Protein Alignment KCNJ10 and Irk1

DIOPT Version :10

• Sequence 1: NP_002232.2
• Gene: KCNJ10 / 3766
• HGNCID: 6256
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 141/346 - (40%)
• Similarity: 203/346 - (58%)
• Gaps: 26/346 - (7%)

Human     9 YSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSA 73
            |.||..:..|.       |:||:.|.|..||...::|.:|..||:|::||.:|.|||:.||:|:|
  Fly   130 YRQTRFSSRRV-------RKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAA 187

Human    74 TFAGTWFLFGVVWYLVAVAHGDL----LELDPP---AN--HTPCVVQVHTLTGAFLFSLESQTTI 129
            :|..:|..||.:|:::|.||.||    |:...|   ||  ||.||.||..:..|||:|:|:||||
  Fly   188 SFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTI 252

Human   130 GYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKP 194
            |||.||::||||.||..:..|.:....::.|:.|...||::||||||:|:.||::||:...:|.|
  Fly   253 GYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVP 317

Human   195 CLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVV 259
            |||.||.:||||.:|...|..::::...|||||.:...|..:....|...|....|.|.|..|.:
  Fly   318 CLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKI 382

Human   260 DETSPLKDLPLRSGEGD-----FELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISL-S 318
            |..|||..|    ...|     ||:|::|.|.:|||..|.|.|:||||.|:|||:.|...:|. .
  Fly   383 DRNSPLYML----SASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRK 443

Human   319 ASGKYIADFSLFDQVVKVASP 339
            .:|:|..|::||:....|.:|
  Fly   444 ETGEYEVDYTLFNNTYDVDTP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNJ10	NP_002232.2	IRK	31..172	CDD:460023	64/149 (43%)
		Selectivity filter. /evidence=ECO:0000250	128..133		4/4 (100%)
		IRK_C	179..354	CDD:465439	63/167 (38%)
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	64/149 (43%)
		IRK_C	302..476	CDD:465439	63/167 (38%)