DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNJ10 and kcnj10a

DIOPT Version :9

Sequence 1:	NP_002232.2	Gene:	KCNJ10 / 3766	HGNCID:	6256	Length:	379	Species:	Homo sapiens
Sequence 2:	XP_003198936.1	Gene:	kcnj10a / 100538267	ZFINID:	ZDB-GENE-130726-1	Length:	425	Species:	Danio rerio

Alignment Length:	414	Identity:	269/414 - (64%)
Similarity:	320/414 - (77%)	Gaps:	36/414 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     2 TSVAKVYYSQTTQTESRPLMGPG-------------IRRRRVLTKDGRSNVRMEHIADKRFLYLK 53
            :|..||.:|||.....:||:|.|             .||||||:||||||||:||::.:..|||:
Zfish    12 SSPQKVCHSQTQTDVLKPLLGGGGGGTSTGNGPAALRRRRRVLSKDGRSNVRIEHVSGRGTLYLR 76

Human    54 DLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGA 118
            ||||||:||||||||.|||||||||||:|||:|||||:.||||||.|||:||||||:||.|||||
Zfish    77 DLWTTFLDMQWRYKLFLFSATFAGTWFVFGVLWYLVALVHGDLLEFDPPSNHTPCVMQVQTLTGA 141

Human   119 FLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQ 183
            ||||||||||||||||.|:|||||||:|||.|||:|.::|||||||||||:||||||.||::|||
Zfish   142 FLFSLESQTTIGYGFRCITEECPLAIILLIVQLVITMVMEIFITGTFLAKVARPKKRGETVKFSQ 206

Human   184 HAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPF 248
            |||||:|.|:|||||||||||||||:||||:||||||.||||||.:||:|.||.|||||:|||||
Zfish   207 HAVVANHEGRPCLMIRVANMRKSLLLGCQVSGKLLQTSQTKEGETVRLDQRNVAFQVDTSSDSPF 271

Human   249 LILPLTFYHVVDETSPLKDLPLRSGE------GDFELVLILSGTVESTSATCQVRTSYLPEEILW 307
            ||||||||||:|:.|||:....:.|.      .||||::|:|.|||.|||||||||||||:||||
Zfish   272 LILPLTFYHVIDDNSPLRAWAAKGGGWTDPELADFELLVIMSATVEPTSATCQVRTSYLPDEILW 336

Human   308 GYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRD-------------STVRYGDPEKLKLEE 359
            ||||.|.:|||.||||:|||:.||:|.|..:|...:.             |..:..|.||::|||
Zfish   337 GYEFPPVVSLSPSGKYVADFAFFDKVAKTKTPPLFKQAPPSHTQTPQHQGSGEKGADTEKMRLEE 401

Human   360 SLREQAEKE----GSALSVRISNV 379
            |.||:..::    ...||||||||
Zfish   402 SYREERGRDRGRVRDQLSVRISNV 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNJ10	NP_002232.2	IRK	31..172	CDD:395797	112/140 (80%)
		Selectivity filter. /evidence=ECO:0000250	128..133		4/4 (100%)
		IRK_C	179..354	CDD:407551	119/193 (62%)
kcnj10a	XP_003198936.1	IRK	54..368	CDD:279361	235/313 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194335795
Domainoid	1	1.000	248	1.000	Domainoid score	I9769
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1689
Inparanoid	1	1.050	529	1.000	Inparanoid score	I6119
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D269493at7742
OrthoFinder	1	1.000	-	-		FOG0009541
OrthoInspector	1	1.000	-	-		otm27289
orthoMCL	1	0.900	-	-		OOG6_118966
Panther	1	1.100	-	-	LDO	PTHR11767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7822
SonicParanoid	1	1.000	-	-		X7286
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.440