DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9890 and znf277

DIOPT Version :9

Sequence 1:	NP_611750.1	Gene:	CG9890 / 37659	FlyBaseID:	FBgn0034814	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_956724.1	Gene:	znf277 / 393402	ZFINID:	ZDB-GENE-040426-1633	Length:	440	Species:	Danio rerio

Alignment Length:	465	Identity:	165/465 - (35%)
Similarity:	234/465 - (50%)	Gaps:	62/465 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HEVAVSG-GDSSLEEI-------TGSSKLKPSKNTAIKCLKCDKVYIFP-SDKDDCLAHLYMEHR 58
            |.:.|:| .|..||.:       .|......|....:.|..|..  :|| |:||..|.|:.:||:
Zfish     6 HNINVTGKQDCILEPLCFPENFSDGVCLASSSDGCPMTCALCPD--LFPASEKDQLLKHMVLEHK 68

  Fly    59 LVIADVEDIALLEDYLQYWEKEFHTHEFEQYCTTMFLDQLPDGKYAKNEKYYLLCDILPQDYELR 123
            ||||||:.||....|:.||:|.|.......||:.:..:.  :|...:.|.|:||||.||:|..||
Zfish    69 LVIADVKLIADFSQYMLYWKKRFTEQPITDYCSVIKTNS--EGPVDQQEHYFLLCDALPEDRILR 131

  Fly   124 RRLKEKRLSEALERHQFELTDRTFSKECLFCRAIIKGLRADYLDHLFDKHFLLVGKPEKLVYVDE 188
            .:|:::||.|.||:.|.|..|.||.:.|:||.....|.|:..|:|:..:|...:|.|:.:||.||
Zfish   132 EQLQQRRLEEVLEQQQKERDDETFHRICMFCSEEFTGNRSSLLNHMAKEHSFSIGLPDNIVYCDE 196

  Fly   189 LLDHLEENLNRLMCLYCEKIFRDRPTLKEHMRKKGHKRINPNRREYDKYFLINYNRVPTAPTPRK 253
            .|:.||..|:.:.||||||.|||:.|||:|||||.|:|||.....||::::|||
Zfish   197 FLNTLESKLDNMQCLYCEKTFRDKTTLKDHMRKKQHRRINARNHGYDRFYVINY----------- 250

  Fly   254 QHLQKRRRETASVSTVADPETGSVDFDKHFARPDSDGEHDSDWSDWAADGEPSSIKCLFCHHLGD 318
            ..|.|...|..|            :.|:....     :.|.|||||.|  .|....||||....:
Zfish   251 LELGKTWEEVQS------------EDDREMLE-----DEDDDWSDWQA--HPVCAVCLFCDQQAE 296

  Fly   319 NFTALKKHMHEVHRLDFEKATS--SLNFYQRVKVVNYLRRQMCLLRCVTCDLQFDEEELLVEHMA 381
            ....:..||.|.|..|..|...  ||.|||:||:|||:||::...||..|..:|:.:|.||:|:.
Zfish   297 TMDKIYTHMQETHEFDLHKLKMDLSLKFYQQVKLVNYIRRELHQCRCYCCQEKFESKEELVQHLV 361

  Fly   382 QESH-HGIGDKESWDKPEFFFPYIENDGLLCVLDDSGGDDPDVD---TVRIISEDSLAQINKDAE 442
            ...| ..:.|...||:|:::||..|||.||..|.|...:....:   .|.:|:||
Zfish   362 TAGHVMQLPDVSHWDQPQYYFPTYENDALLTALSDGESESEGTNHSSEVPVIAED---------- 416

  Fly   443 RLSLENFKLL 452
               :.|.|:|
Zfish   417 ---ISNLKVL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9890	NP_611750.1	zf-C2H2_2	151..238	CDD:289522	41/86 (48%)
CG9890	NP_611750.1	zf-C2H2_2	310..405	CDD:289522	37/97 (38%)
znf277	NP_956724.1	zf-C2H2_2	159..246	CDD:289522	41/86 (48%)
		C2H2 Zn finger	210..232	CDD:275371	17/21 (81%)
		zf-C2H2_2	288..386	CDD:289522	37/97 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592740
Domainoid	1	1.000	107	1.000	Domainoid score	I6481
eggNOG	1	0.900	-	-		E1_KOG2482
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11087
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2874
OMA	1	1.010	-	-		QHG54460
OrthoDB	1	1.010	-	-		D1498904at2759
OrthoFinder	1	1.000	-	-		FOG0005654
OrthoInspector	1	1.000	-	-		oto39046
orthoMCL	1	0.900	-	-		OOG6_104708
Panther	1	1.100	-	-	LDO	PTHR13267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810