DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fatp2 and FAT1

DIOPT Version :9

Sequence 1:	NP_995925.2	Gene:	Fatp2 / 37657	FlyBaseID:	FBgn0265187	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_009597.2	Gene:	FAT1 / 852329	SGDID:	S000000245	Length:	669	Species:	Saccharomyces cerevisiae

Alignment Length:	638	Identity:	203/638 - (31%)
Similarity:	310/638 - (48%)	Gaps:	65/638 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 WFYIAAVTTPRDTVALFAYIRVLLFIKRQERKNLNIGDIFESNVARQPDKLAI--------VSES 162
            |:.|     |....::|.||   :.::|...:|..   :|...|.:..|.|||        ..|.
Yeast    54 WYII-----PYFLKSVFCYI---IDVRRHRFQNWY---LFIKQVQQNGDHLAISYTRPMAEKGEF 107

  Fly   163 QQWTFRQVNEHS--NRVANVFH-SHGYKKGDVVGLLLENRAEFVATWLGLSKIGVITPLINTNLR 224
            |..||..:..::  .|::::.| .:..:.||.|.:...|:..||..||.|..||.|...:|.|.:
Yeast   108 QLETFTYIETYNIVLRLSHILHFDYNVQAGDYVAIDCTNKPLFVFLWLSLWNIGAIPAFLNYNTK 172

  Fly   225 GASLQHSITVGQCTALIYGAS----FRSAVMDIAKDLPAHVGLYQFNDESNQEVVASEGLSQGLA 285
            |..|.||:.:...|.:.....    .|.:..:|...||.....|....:...|::.|:  |....
Yeast   173 GTPLVHSLKISNITQVFIDPDASNPIRESEEEIKNALPDVKLNYLEEQDLMHELLNSQ--SPEFL 235

  Fly   286 QQLNGLLETAAKDKVAAGASRADHHDKLVYIYTSGTTGLPKAAVITHSRYFFIAAGIHYTLGFKD 350
            ||          |.|.......|....:: |||||||||||:|:::..:.........:.|...:
Yeast   236 QQ----------DNVRTPLGLTDFKPSML-IYTSGTTGLPKSAIMSWRKSSVGCQVFGHVLHMTN 289

  Fly   351 QDVFYTPLPLYHTAGGVMSMGQALLFGSTVVIRKKFSASGYFSDCARFQCTVGQYIGEMARYILA 415
            :...:|.:||:|:...::.....|..|..:.:..|||||.::........|..||:||:.||:|.
Yeast   290 ESTVFTAMPLFHSTAALLGACAILSHGGCLALSHKFSASTFWKQVYLTGATHIQYVGEVCRYLLH 354

  Fly   416 TPSAPHDRNHQVRMVFGNGLRPQIWPQFVERFGIRKVGEFYGATE---GNANIMNNDSTVGAIGF 477
            ||.:.:::.|:|::.:||||||.||..|.:||.|..:||||.|||   ........|..:||...
Yeast   355 TPISKYEKMHKVKVAYGNGLRPDIWQDFRKRFNIEVIGEFYAATEAPFATTTFQKGDFGIGACRN 419

  Fly   478 ISRILPQI--YPISIIKADPHTGEPL-RNSQGLCERCEADEPG-----VFVGKIVRGNPCREFLG 534
            ...|:...  :..::::.||:....: |||:|.||.....|||     :|..|    .|...|.|
Yeast   420 YGTIIQWFLSFQQTLVRMDPNDDSVIYRNSKGFCEVAPVGEPGEMLMRIFFPK----KPETSFQG 480

  Fly   535 YV-DQKASSKKVVHDVFSKGDMAFISGDLLVADERGYLYFKDRTGDTFRWKGENVSTSEVEAQL- 597
            |: :.|.:..|||.|||.:||..:..||||.|||.|..||.||.|||||||.|||||:|||.||
Yeast   481 YLGNAKETKSKVVRDVFRRGDAWYRCGDLLKADEYGLWYFLDRMGDTFRWKSENVSTTEVEDQLT 545

  Fly   598 -SNLAGYKDVIVYGVSIPNTEGRAGMAAIYDPTREVNVSQ----LGVELAK-SLPNYARPQFLRF 656
             ||...|..|:|.|:.:|..|||||.|.|......::::.    |...|:: :||:||.|.|::|
Yeast   546 ASNKEQYAQVLVVGIKVPKYEGRAGFAVIKLTDNSLDITAKTKLLNDSLSRLNLPSYAMPLFVKF 610

  Fly   657 LRKIDLTGTFKLRKVELQQQGFNPEIID--DELFYAQPDGVYAPLTPSVYERI 707
            :.:|.:|...|:.|...::|.. |:.:|  |.:|:.:....|..||.:.:|.|
Yeast   611 VDEIKMTDNHKILKKVYREQKL-PKGLDGNDTIFWLKNYKRYEVLTAADWEAI 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp2	NP_995925.2	PRK08279	115..714	CDD:236217	201/629 (32%)
Fatp2	NP_995925.2	AFD_class_I	163..680	CDD:302604	179/542 (33%)
FAT1	NP_009597.2	FATP_chFAT1_like	107..634	CDD:341260	179/544 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I593
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	1	1.000	-	-		otm46783
orthoMCL	1	0.900	-	-		OOG6_100576
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2110
SonicParanoid	1	1.000	-	-		X222
TreeFam	0	0.000	Not matched by this tool.
	9	8.890