DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fatp2 and Acsl4

DIOPT Version :9

Sequence 1:	NP_995925.2	Gene:	Fatp2 / 37657	FlyBaseID:	FBgn0265187	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_997508.1	Gene:	Acsl4 / 50790	MGIID:	1354713	Length:	711	Species:	Mus musculus

Alignment Length:	763	Identity:	163/763 - (21%)
Similarity:	259/763 - (33%)	Gaps:	224/763 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PWYGVATLYAALISILLVRPGWRWFYIAAVT-------------------TPRDTVALFAYIRVL 128
            |.:.:.|:|:|||.|       .|:::....                   :|..:|..|..:.|:
Mouse    14 PVHLLITIYSALIFI-------PWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVI 71

  Fly   129 ----------LF----IKRQERKNLNIGDIFESNVARQPD----KLAIVSESQQWTFRQVNEHSN 175
                      ||    .|..::.:|...:|.......||:    |..|:...:...:.:||...|
Mouse    72 DIPGADTLDKLFDHAVAKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWINYLEVNCRVN 136

  Fly   176 RVANVFHSHGYKKGDVVGLLLENRAEFVATWLGLSKIGVITPLINTNLRGASLQHSITVGQCTAL 240
            ...:...:.|.|..:.:.:..|.|||::.......|.......:...|...::.|.:...:.:.|
Mouse   137 NFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEASYL 201

  Fly   241 IYG-----ASFRSAVMDIAKDLPAHVGLYQFNDESNQEVVASEGLSQGLAQQLNGLLETAAK-DK 299
            |..     :..::|::||  :...|: :|..|...|: ....|||.   ...:..:.|..|| :.
Mouse   202 ITSVELLESKLKAALVDI--NCVKHI-IYVDNKTINR-AEYPEGLE---IHSMQSVEELGAKPEN 259

  Fly   300 VAAGASRADHHDKLVYIYTSGTTGLPKAAVITHSRYFFIAAGIHYT------LGFKDQDVFYTPL 358
            ::...||....|..:.:||||:||.||..::.||.   :.||:...      ||.||..:.|  |
Mouse   260 LSVPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSN---LIAGMTGQCERIPGLGPKDTYIGY--L 319

  Fly   359 PLYH----TAG-GVMSMGQALLFGSTVVIRKKFS--ASGYFSDCARFQCTVGQYIGE-MARYILA 415
            ||.|    ||. ...:.|..:.:.|.:.:..:.|  ..|...||...:.|:...:.| |.|....
Mouse   320 PLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKN 384

  Fly   416 TPSAPHDRNH----------------------------------------QVRMVFGNG--LRPQ 438
            ..|...:.|:                                        .|||:...|  |.||
Mouse   385 VMSKVQEMNYVQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQ 449

  Fly   439 IWPQFVERFGIRKVGEFYGATE--GNANIMN-NDSTVGAIGFISRILPQIYPISIIKADPHTGEP 500
            . .:|:.......:|:.||.||  |...:.. .|.|.|.:                      |.|
Mouse   450 T-HRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRV----------------------GAP 491

  Fly   501 LRNSQGLCERCEA-----DEPGVFV-------GKIVRGNPCREFLGYVDQKASSKKVVHD--VFS 551
            |     :|  ||.     .|.|..|       |:||.|.. ...:||.   .:.:|...|  |..
Mouse   492 L-----IC--CEIKLKDWQEGGYTVHDKPNPRGEIVIGGQ-NISMGYF---KNEEKTAEDYCVDE 545

  Fly   552 KGDMAFISGDLLVADERGYLYFKDRTGDTFRWK-GENVSTSEVEAQLSNLAGYKDVIVYGVS--- 612
            .|...|.:||:......|.|...||..|..:.: ||.||..:|||.|.|.....::..:..|
Mouse   546 NGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQS 610

  Fly   613 ------IPNTEGRAGMAAIYDPTREVNVSQLGV---------------ELAKSLPNYARPQFL-R 655
                  :||.:....:|           .|.||               |:.|.:...|....| |
Mouse   611 YVISFVVPNQKKLTLLA-----------QQKGVEGSWVDICNNPAMEAEILKEIREAANAMKLER 664

  Fly   656 FLRKID--------------LTGTFKLRKVELQQQGFNPEIIDDELFY 689
            |...|.              :|..|||::.||:    |..:.|.|..|
Mouse   665 FEIPIKVRLSPEPWTPETGLVTDAFKLKRKELK----NHYLKDIERMY 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp2	NP_995925.2	PRK08279	115..714	CDD:236217	155/712 (22%)
Fatp2	NP_995925.2	AFD_class_I	163..680	CDD:302604	138/635 (22%)
Acsl4	NP_997508.1	LC_FACS_euk1	121..696	CDD:341294	136/631 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930