DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fatp2 and SLC27A1

DIOPT Version :9

Sequence 1:	NP_995925.2	Gene:	Fatp2 / 37657	FlyBaseID:	FBgn0265187	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_011526302.1	Gene:	SLC27A1 / 376497	HGNCID:	10995	Length:	658	Species:	Homo sapiens

Alignment Length:	661	Identity:	304/661 - (45%)
Similarity:	415/661 - (62%)	Gaps:	35/661 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 APVLTAISGLILYYQG-PWYGVATLYAALISILLVRPGWRWFYIAAVTTPRDTVALFAYIRVLLF 130
            |...:.:|..:|:..| ||...|   ||.:.:.:...|||:..|...|..||...|...|||.|.
Human     6 AGAASVVSLALLWLLGLPWTWSA---AAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLE 67

  Fly   131 IKRQERKNLNIGDIFESNVARQPDKLAIV--SESQQWTFRQVNEHSNRVANVFHSHGYKKGDVVG 193
            ::|.:|....|..||::.|.|||::||:|  ...:.|||.|::.:||.|||:|...|:..||||.
Human    68 LRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVA 132

  Fly   194 LLLENRAEFVATWLGLSKIGVITPLINTNLRGASLQHSITVGQCTALIYGASFRSAVMDIAKDLP 258
            :.||.|.|||..||||:|.|:...|:|.|||...|...:......|||:|....:||.:::
Human   133 IFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVS---- 193

  Fly   259 AHVG--LYQF--NDESNQEVVASEGLSQGLAQQLNGLLETAAKDKVAAGASRADHHDKLVYIYTS 319
            .|:|  |.:|  .|...:.::....|       |:.||:.|:...:|...|:. ..|:|.|||||
Human   194 GHLGKSLIKFCSGDLGPEGILPDTHL-------LDPLLKEASTAPLAQIPSKG-MDDRLFYIYTS 250

  Fly   320 GTTGLPKAAVITHSRYFFIAAGIHYTLGFKDQDVFYTPLPLYHTAGGVMSMGQALLFGSTVVIRK 384
            |||||||||::.||||:.:||..|:....:..||.|..|||||:||.::.:||.|::|.|||:||
Human   251 GTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRK 315

  Fly   385 KFSASGYFSDCARFQCTVG------------QYIGEMARYILATPSAPHDRNHQVRMVFGNGLRP 437
            |||||.::.||.::.||:.            |||||:.||:|..|....:|.|:||:..||||||
Human   316 KFSASRFWDDCIKYNCTINGVRHCRLLCLVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRP 380

  Fly   438 QIWPQFVERFGIRKVGEFYGATEGNANIMNNDSTVGAIGFISRILPQIYPISIIKADPHTGEPLR 502
            .||.:|.||||:|::||||||||.|.:|.|.|..||:.||.|||||.:|||.::|.:..|.|.||
Human   381 AIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLR 445

  Fly   503 NSQGLCERCEADEPGVFVGKIVRGNPCREFLGYVDQKASSKKVVHDVFSKGDMAFISGDLLVADE 567
            ::||||..|:|.|||:.||:|.:.:|.|.|.|||.:.|:|||:.|.||||||.|::|||:||.||
Human   446 DAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDE 510

  Fly   568 RGYLYFKDRTGDTFRWKGENVSTSEVEAQLSNLAGYKDVIVYGVSIPNTEGRAGMAAIYDPTREV 632
            .||:||:||:||||||:||||||:|||..||.|.|..||.||||::|..||:|||||:.||...:
Human   511 LGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLL 575

  Fly   633 NVSQLGVELAKSLPNYARPQFLRFLRKIDLTGTFKLRKVELQQQGFNPEIIDDELFYAQ-PDGVY 696
            :.:.:..||.|.|..||||.|||.|.::|.|||||::|..||::||:|....|.||:.. ..|.|
Human   576 DPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHY 640

  Fly   697 APLTPSVYERI 707
            .||..:||.||
Human   641 LPLNEAVYTRI 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp2	NP_995925.2	PRK08279	115..714	CDD:236217	290/612 (47%)
Fatp2	NP_995925.2	AFD_class_I	163..680	CDD:302604	259/532 (49%)
SLC27A1	XP_011526302.1	PRK08279	42..656	CDD:236217	293/622 (47%)
		metallo-hydrolase-like_MBL-fold	64..>135	CDD:304873	29/70 (41%)
		AFD_class_I	101..623	CDD:302604	259/533 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149005
Domainoid	1	1.000	430	1.000	Domainoid score	I595
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1072
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63225
OrthoDB	1	1.010	-	-		D390277at33208
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	1	1.000	-	-		mtm8641
orthoMCL	1	0.900	-	-		OOG6_100576
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2110
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940