DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fatp2 and Slc27a4

DIOPT Version :9

Sequence 1:	NP_995925.2	Gene:	Fatp2 / 37657	FlyBaseID:	FBgn0265187	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001094176.1	Gene:	Slc27a4 / 311839	RGDID:	1307383	Length:	643	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	293/640 - (45%)
Similarity:	393/640 - (61%)	Gaps:	31/640 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PWYGVATLYAALISILLVRPGWRWFYIAAVTTPRDTVALFAYIRVLLFIKR--QERKNLNIGDIF 145
            ||..|.   .:|:.:.|...|||:..:...|..||.......::|...::|  ||||.:.:  :|
  Rat    21 PWTQVG---FSLLLLYLGSGGWRFIRVFIKTVRRDVFGGMVLLKVKTKVRRYLQERKTVPL--LF 80

  Fly   146 ESNVARQPDKLAIVSE--SQQWTFRQVNEHSNRVANVFHSHGYKKGDVVGLLLENRAEFVATWLG 208
            .|.|.|.|||.|::.|  :..|||||::::|:.|||...:.|...|:||.|.:|||.|||..|||
  Rat    81 ASVVRRHPDKTALIFEGTNTHWTFRQLDDYSSSVANFLQARGLVSGNVVALFMENRNEFVGLWLG 145

  Fly   209 LSKIGVITPLINTNLRGASLQHSITVGQCTALIYGASFRSAVMDIAKDLPAHVGLYQFNDESNQE 273
            ::|:||...|||||||..:|:|.:...:..|||:|:...|||.:|...|...:.|:.........
  Rat   146 MAKLGVEAALINTNLRRDALRHCLDTSKARALIFGSEMASAVYEIQAILDPTLTLFCSGSWEPST 210

  Fly   274 VVASEGLSQGLAQQLNGLLETAAK------DKVAAGASRADHHDKLVYIYTSGTTGLPKAAVITH 332
            |.|:       .:.|:.|||.|.|      ||        ...|||.||||||||||||||::.|
  Rat   211 VPAN-------TEHLDPLLEDAPKHLPSIPDK--------GFTDKLFYIYTSGTTGLPKAAIVVH 260

  Fly   333 SRYFFIAAGIHYTLGFKDQDVFYTPLPLYHTAGGVMSMGQALLFGSTVVIRKKFSASGYFSDCAR 397
            |||:.:||.::|....:..|:.|..|||||:||.::.:||.:|.|.|||||||||||.::.||.:
  Rat   261 SRYYRMAALVYYGFRMRPDDIVYDCLPLYHSAGNIVGIGQCVLHGMTVVIRKKFSASRFWDDCIK 325

  Fly   398 FQCTVGQYIGEMARYILATPSAPHDRNHQVRMVFGNGLRPQIWPQFVERFGIRKVGEFYGATEGN 462
            :.||:.|||||:.||:|..|....:..|:|||..|||||..||..|..||.|.:|.|||||||.|
  Rat   326 YNCTIVQYIGELCRYLLNQPPREAESRHKVRMALGNGLRQSIWTDFSSRFHIPQVAEFYGATECN 390

  Fly   463 ANIMNNDSTVGAIGFISRILPQIYPISIIKADPHTGEPLRNSQGLCERCEADEPGVFVGKIVRGN 527
            .::.|.||.|||.||.||||..:|||.:::.:..|.|.:|...|:|..|:..:||..||:|::.:
  Rat   391 CSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGQPGQLVGRIIQQD 455

  Fly   528 PCREFLGYVDQKASSKKVVHDVFSKGDMAFISGDLLVADERGYLYFKDRTGDTFRWKGENVSTSE 592
            |.|.|.||::|.|::||:..|||.|||.|:::||:||.||.|||||:||||||||||||||||:|
  Rat   456 PLRRFDGYLNQGANNKKIASDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTE 520

  Fly   593 VEAQLSNLAGYKDVIVYGVSIPNTEGRAGMAAIYDPTREVNVSQLGVELAKSLPNYARPQFLRFL 657
            ||..||.|....||.||||.:|..||||||||:..||...::......|.|.||.||||.|||||
  Rat   521 VEGTLSRLLQMADVAVYGVEVPGAEGRAGMAAVASPTSNCDLESFAQTLKKELPLYARPIFLRFL 585

  Fly   658 RKIDLTGTFKLRKVELQQQGFNPEIIDDELFYAQP-DGVYAPLTPSVYERIVRNE 711
            .::..|||||.:|.||:::||:|.::.|.|||... .|.|..|....|.||...|
  Rat   586 PELHKTGTFKFQKTELRKEGFDPSVVKDPLFYLDARTGCYVALDQEAYTRIQAGE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp2	NP_995925.2	PRK08279	115..714	CDD:236217	284/608 (47%)
Fatp2	NP_995925.2	AFD_class_I	163..680	CDD:302604	255/522 (49%)
Slc27a4	NP_001094176.1	PRK08279	75..643	CDD:236217	276/583 (47%)
Slc27a4	NP_001094176.1	hsFATP4_like	99..608	CDD:213305	255/523 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342903
Domainoid	1	1.000	423	1.000	Domainoid score	I602
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68437
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1028
OMA	1	1.010	-	-		QHG63225
OrthoDB	1	1.010	-	-		D298283at2759
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	1	1.000	-	-		mtm9119
orthoMCL	1	0.900	-	-		OOG6_100576
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910