Protein Alignment twi and HAND2

DIOPT Version :9

• Sequence 1: NP_001033967.1
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_068808.1
• Gene: HAND2 / 9464
• HGNCID: 4808
• Length: 217
• Species: Homo sapiens
• Alignment Length: 181
• Identity: 59/181 - (32%)
• Similarity: 84/181 - (46%)
• Gaps: 44/181 - (24%)

  Fly   256 PHQQSHAQMHFQNAYRQSFEGYEPANSLNGSAYSSSDR---DDMEYARHNALSSVSDLNGGVMSP 317
            ||   |..:|        .|||..|.:...:|.:::.|   ::..|. |..|....:::....|.
Human     8 PH---HPVVH--------HEGYPFAAAAAAAAAAAASRCSHEENPYF-HGWLIGHPEMSPPDYSM 60

  Fly   318 ACLAD----DGSAGSLLDGSDAGG-------KAFRKPRRRLKRKPSKTEETDEFSNQRVMANVRE 371
            |....    .|:||  ||.|..||       .....||      |.|         :|..||.:|
Human    61 ALSYSPEYASGAAG--LDHSHYGGVPPGAGPPGLGGPR------PVK---------RRGTANRKE 108

  Fly   372 RQRTQSLNDAFKSLQQIIPTLPSD-KLSKIQTLKLATRYIDFLCRMLSSSD 421
            |:||||:|.||..|::.||.:|:| |||||:||:|||.||.:|..:|:..|
Human   109 RRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDD 159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_001033967.1	HLH	363..413	CDD:278439	29/50 (58%)
HAND2	NP_068808.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..116		17/54 (31%)
		bHLH_TS_HAND2	100..161	CDD:381477	32/60 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5507
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.830