Protein Alignment twi and MSC

DIOPT Version :10

• Sequence 1: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_005089.2
• Gene: MSC / 9242
• HGNCID: 7321
• Length: 206
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 61/215 - (28%)
• Similarity: 90/215 - (41%)
• Gaps: 37/215 - (17%)

  Fly   244 QQQQSQQLQQQQPHQQSHAQMHFQNAYRQSFEGYEP--ANSLNGSAYSSSDRDDMEYARHNALSS 306
            ::.:.:.||::.|...|.         |....|.|.  |:..:.|:....|.|..|  ...||.:
Human    10 EEMELRGLQREYPVPASK---------RPPLRGVERSYASPSDNSSAEEEDPDGEE--ERCALGT 63

  Fly   307 VSDLNGGVMSPACLADDGSAGSLLDGSDAGGKAFRKPRRRLKRKPSKTEETDEFSNQRVMANVRE 371
            .....|.......:|..|.||    ||..||.  :||      .|:|....:...:||..||.||
Human    64 AGSAEGCKRKRPRVAGGGGAG----GSAGGGG--KKP------LPAKGSAAECKQSQRNAANARE 116

  Fly   372 RQRTQSLNDAFKSLQQIIPTLPSD-KLSKIQTLKLATRYIDFLCRMLSSS--------DISLLKA 427
            |.|.:.|:.||..|:..:|.:|.| ||||:.||:||:.||..|.::|...        .::|...
Human   117 RARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYENGYVHPVNLTWP 181

  Fly   428 LEAQGSPSAYGSASSLLSAA 447
            ....|.|.   |.:..:|||
Human   182 FVVSGRPD---SDTKEVSAA 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	27/66 (41%)
MSC	NP_005089.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		31/127 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	71..76		0/4 (0%)
		bHLH_TS_musculin	105..170	CDD:381546	27/64 (42%)