DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twi and Atoh8

DIOPT Version :9

Sequence 1:	NP_001033967.1	Gene:	twi / 37655	FlyBaseID:	FBgn0003900	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_722473.1	Gene:	Atoh8 / 71093	MGIID:	1918343	Length:	322	Species:	Mus musculus

Alignment Length:	253	Identity:	59/253 - (23%)
Similarity:	93/253 - (36%)	Gaps:	75/253 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 LPTTVDEVASAQSCPGVQSTCTSPQSHFDFPDEELPEHKAQVFLPLYNNQQQQSQQLQQQQPHQQ 259
            |||.....||....||      .|::| .|.::.|   :.::.|.....:..||..|......|:
Mouse   123 LPTPPPPPASQSLAPG------DPEAH-SFREQAL---RPRILLCAPPARPTQSAPLAPPAAPQE 177

  Fly   260 SHAQMHFQNAYRQSFEGYEPANSLNGSAYSSSDRDDMEYARHNALSSVSDLNGGVMSPACLADDG 324
            |..:.             .|......|:|||...  :.|..|                    .|.
Mouse   178 SPVRP-------------APPTRPGESSYSSISH--VIYNNH--------------------PDS 207

  Fly   325 SAGSLLDGSDAGGKAFRKPRRRLKRKPSKTEETDEF-SNQRVMANVRERQRTQSLNDAFKSLQQI 388
            ||               .||:|.....:.:.|.... ..:|::||.|||.|..:::.||::|::.
Mouse   208 SA---------------SPRKRPGEATAASTEIKALQQTRRLLANARERTRVHTISAAFEALRKQ 257

  Fly   389 IPTLP-SDKLSKIQTLKLATRYIDFLCRMLS---SSDISLL----------KALEAQG 432
            :|... ..||||:..|::|..||..|.|:..   |:|.|.|          :.|:|:|
Mouse   258 VPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEG 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_001033967.1	HLH	363..413	CDD:278439	19/50 (38%)
Atoh8	NP_722473.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..144		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..221		18/111 (16%)
		Basic motif, degenerate. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	231..244		6/12 (50%)
		HLH	232..283	CDD:278439	19/50 (38%)
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	245..283		12/37 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910