Protein Alignment twi and TCF21

DIOPT Version :10

• Sequence 1: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_003197.2
• Gene: TCF21 / 6943
• HGNCID: 11632
• Length: 179
• Species: Homo sapiens
• Alignment Length: 182
• Identity: 50/182 - (27%)
• Similarity: 73/182 - (40%)
• Gaps: 49/182 - (26%)

  Fly   303 ALSSVSDLNGGVMSPACLADDG-----------------SAGSLLDGSDAGGKAFRKPRRR--LK 348
            :||.|.||....|    |..||                 .:.:..:||...|:.....||:  .|
Human     5 SLSDVEDLQEVEM----LECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTK 65

  Fly   349 RKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQQIIPTLPSD-KLSKIQTLKLATRYIDF 412
            :.|......:....||..||.|||.|.:.|:.||..|:..:|.:|.| ||||:.||:||:.||..
Human    66 KSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAH 130

  Fly   413 LCRMLSSS--------DISLLKALEAQGSPSAYGSASSLLSAAANGAEADLK 456
            |.::|::.        .::|.......|.|                 |:|||
Human   131 LRQILANDKYENGYIHPVNLTWPFMVAGKP-----------------ESDLK 165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	27/66 (41%)
TCF21	NP_003197.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..87		13/66 (20%)
		bHLH_TS_TCF21_capsulin	77..140	CDD:381547	27/62 (44%)