DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twi and TCF15

DIOPT Version :9

Sequence 1:	NP_001033967.1	Gene:	twi / 37655	FlyBaseID:	FBgn0003900	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_004600.3	Gene:	TCF15 / 6939	HGNCID:	11627	Length:	199	Species:	Homo sapiens

Alignment Length:	131	Identity:	50/131 - (38%)
Similarity:	65/131 - (49%)	Gaps:	26/131 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 QRVMANVRERQRTQSLNDAFKSLQQIIPTLPSD-KLSKIQTLKLATRYIDFLCRMLSSSDISLLK 426
            ||..||.|||.||||:|.||.:|:.:|||.|.| |||||:|::||:.||..|..:|...|    .
Human    73 QRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETVRLASSYIAHLANVLLLGD----S 133

  Fly   427 ALEAQGSPSAYGSASSLLSAAAN-------------------GAEADL--KCLRKANGAPIIPPE 470
            |.:.|....|.|||...:.|||:                   |...||  .||:....||:..|.
Human   134 ADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPR 198

  Fly   471 K 471
            :
Human   199 R 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_001033967.1	HLH	363..413	CDD:278439	30/50 (60%)
TCF15	NP_004600.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..67
TCF15	NP_004600.3	bHLH_TS_TCF15_paraxis	66..131	CDD:381476	32/57 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840