Protein Alignment twi and Neurod2

DIOPT Version :10

• Sequence 1: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_062199.2
• Gene: Neurod2 / 54276
• RGDID: 3166
• Length: 382
• Species: Rattus norvegicus
• Alignment Length: 269
• Identity: 63/269 - (23%)
• Similarity: 93/269 - (34%)
• Gaps: 94/269 - (34%)

  Fly   310 LNGGVMSPACLADDGSAGSL-------------LDGSDAGGKAFRKPRRRLKRKPSKTEETDEFS 361
            |.|..:....||:....|.|             ||  :|.|:   :|::|..:|...|:...|.|
  Rat    60 LRGEEVPEPTLAEVKEEGELGGEEEEEEEEEEGLD--EAEGE---RPKKRGPKKRKMTKARLERS 119

  Fly   362 N-QRVMANVRERQRTQSLNDAFKSLQQIIPTL-PSDKLSKIQTLKLATRYI-------------- 410
            . :|..||.|||.|...||.|..:|::::|.. .:.|||||:||:||..||
  Rat   120 KLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPD 184

  Fly   411 -----DFLCRMLSSSDISLLKA---------LEAQGSPSA------------------------- 436
                 ..||:.||....:|:..         |..||:..|
  Rat   185 LVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGA 249

  Fly   437 --------------------YGSASSLLSAAANGAEADLKCLRKANGAPIIPPEKLSYLFGVWRM 481
                                |.:|...|.|||.|..|...........|:.||..|:..|.: :.
  Rat   250 QCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSL-KQ 313

  Fly   482 EGDAQHQKA 490
            :....|:|:
  Rat   314 DSSPDHEKS 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	27/77 (35%)
Neurod2	NP_062199.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..129		19/73 (26%)
		bHLH_TS_NeuroD2	88..180	CDD:381563	33/96 (34%)
		Nuclear localization signal. /evidence=ECO:0000255	107..113		1/5 (20%)
		Neuro_bHLH	180..310	CDD:463621	21/129 (16%)