Protein Alignment twi and ASCL2

DIOPT Version :10

• Sequence 1: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_005161.1
• Gene: ASCL2 / 430
• HGNCID: 739
• Length: 193
• Species: Homo sapiens
• Alignment Length: 166
• Identity: 49/166 - (29%)
• Similarity: 68/166 - (40%)
• Gaps: 47/166 - (28%)

  Fly   336 GGKAFRKP------RRRLKRKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQQIIP-TLP 393
            |..|.|:|      |...:|:|: |.||...:......|.|||.|.:.:|..|::|:|.:| ...
Human    19 GCAARRRPASPELLRCSRRRRPA-TAETGGGAAAVARRNERERNRVKLVNLGFQALRQHVPHGGA 82

  Fly   394 SDKLSKIQTLKLATRYIDFLCRMLSSSDI---SLLKALEAQ------------------------ 431
            |.||||::||:.|..||..|.|:|:..|.   :|...|..|
Human    83 SKKLSKVETLRSAVEYIRALQRLLAEHDAVRNALAGGLRPQAVRPSAPRGPPGTTPVAASPSRAS 147

  Fly   432 -----------GSP-SAYGSASSLLSAAANGAEADL 455
                       ||| |||.|..|....|.:.||.:|
Human   148 SSPGRGGSSEPGSPRSAYSSDDSGCEGALSPAEREL 183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	23/58 (40%)
ASCL2	NP_005161.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..56		5/19 (26%)
		bHLH_TS_ASCL2_Mash2	49..112	CDD:381586	24/62 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..177		11/58 (19%)