Protein Alignment twi and Neurod2

DIOPT Version :10

• Sequence 1: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_035025.3
• Gene: Neurod2 / 18013
• MGIID: 107755
• Length: 383
• Species: Mus musculus
• Alignment Length: 270
• Identity: 64/270 - (23%)
• Similarity: 95/270 - (35%)
• Gaps: 95/270 - (35%)

  Fly   310 LNGGVMSP----ACLADDGSAGSL----------LDGSDAGGKAFRKPRRRLKRKPSKTEETDEF 360
            |.||...|    |.:.::|..|..          ||  :|.|:   :|::|..:|...|:...|.
Mouse    60 LRGGEEIPEPTLAEVKEEGELGGEEEEEEEEEEGLD--EAEGE---RPKKRGPKKRKMTKARLER 119

  Fly   361 SN-QRVMANVRERQRTQSLNDAFKSLQQIIPTL-PSDKLSKIQTLKLATRYI------------- 410
            |. :|..||.|||.|...||.|..:|::::|.. .:.|||||:||:||..||
Mouse   120 SKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRP 184

  Fly   411 ------DFLCRMLSSSDISLLKA---------LEAQGSPSA------------------------ 436
                  ..||:.||....:|:..         |..||:..|
Mouse   185 DLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAG 249

  Fly   437 ---------------------YGSASSLLSAAANGAEADLKCLRKANGAPIIPPEKLSYLFGVWR 480
                                 |.:|...|.|||.|..|...........|:.||..|:..|.: :
Mouse   250 AQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSL-K 313

  Fly   481 MEGDAQHQKA 490
            .:....|:|:
Mouse   314 QDSSPDHEKS 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	27/77 (35%)
Neurod2	NP_035025.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..130		20/74 (27%)
		bHLH_TS_NeuroD2	89..181	CDD:381563	33/96 (34%)
		Nuclear localization signal. /evidence=ECO:0000255	108..114		1/5 (20%)
		Neuro_bHLH	181..311	CDD:463621	21/129 (16%)