DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twi and Mesp1

DIOPT Version :9

Sequence 1:	NP_001033967.1	Gene:	twi / 37655	FlyBaseID:	FBgn0003900	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_032614.2	Gene:	Mesp1 / 17292	MGIID:	107785	Length:	243	Species:	Mus musculus

Alignment Length:	139	Identity:	47/139 - (33%)
Similarity:	68/139 - (48%)	Gaps:	22/139 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 SDLNGGVMSPACLADDGSAGSLLDGSDAGGKA--FRKPRRRLKRKPSK--TEETDEFSNQRVMAN 368
            ||.| .|.|||..:|.      .||:.|...|  ..:|.|| ...|.:  |..:...|.||..|:
Mouse    26 SDGN-SVCSPAWSSDP------WDGAQASSPAPPCARPARR-AGTPGRRGTHGSRLGSGQRQSAS 82

  Fly   369 VRERQRTQSLNDAFKSLQQIIPTLPS-----DKLSKIQTLKLATRYIDFLCRMLSSSDISLLK-- 426
            .||:.|.::|..|...|::.:|  ||     ..|:||:||:||.|||..|..:|..|:.:|.:
Mouse    83 EREKLRMRTLARALHELRRFLP--PSVAPTGQNLTKIETLRLAIRYIGHLSAVLGLSEDNLRRQR 145

  Fly   427 -ALEAQGSP 434
             |:..:|.|
Mouse   146 HAVSPRGCP 154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twi	NP_001033967.1	HLH	363..413	CDD:278439	22/54 (41%)
Mesp1	NP_032614.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..86		22/67 (33%)
		HLH	77..130	CDD:278439	22/54 (41%)
		CPLCP	153..157		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910