DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and KLF11

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_003588.1	Gene:	KLF11 / 8462	HGNCID:	11811	Length:	512	Species:	Homo sapiens

Alignment Length:	419	Identity:	115/419 - (27%)
Similarity:	154/419 - (36%)	Gaps:	126/419 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPVQVEPVDLSLR---SPRASTSHGSSSSSYKFSSANKAVGYSNGKPGGSSG-----SSSSSGFG 76
            ||...:.|:.|.|   ||:.:.|...:::....|||..|...|.|...|..|     ||.....|
Human   108 PPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQSSAVVARALSGGAERGLLGLEPVPSSPCRAKG 172

  Fly    77 AG---SAGSSSLGAFAAQQQQQLYASSGVSKLPFSPFFAASPFFFTYRRISGSGSGNG--TGSVS 136
            ..   ..|.|....|...|....                         |:|.|..|..  .|...
Human   173 TSVIRHTGESPAACFPTIQTPDC-------------------------RLSDSREGEEQLLGHFE 212

  Fly   137 VKQE---------DNNNSCS-----------YNNGSSSGGAGSAAN-SMQDYESKFSLLSLFKNP 180
            ..|:         .|..||.           .:.|..:|..|:... |.::||:
Human   213 TLQDTHLTDSLLSTNLVSCQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYEN----------- 266

  Fly   181 YKFAGGDGQASRKTSP------------------TGGSS-----------------KPLASNSSP 210
                    ...|||:|                  ||.||                 :|:.:.::|
Human   267 --------DLPRKTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQAAP 323

  Fly   211 SWKS-YAGSGSPHAALNPAFGGMGRGATRKDNSSFSGINFGGG------GSAFGFTTSSDSMANG 268
            :.:. :.|...|..|:...   :.:||........:.:...|.      ..|..|.|||.:..
Human   324 APQPVFVGPAVPQGAVMLV---LPQGALPPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNCV-- 383

  Fly   269 GYNDLSKNRKVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRK 333
            ...|.|:.|. :.|...||.|.|.||||||||.||||||||:.|:|:||..:|||||||:||.|.
Human   384 PQVDFSRRRN-YVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRT 447

  Fly   334 HTGVKPFRCQLCTRSFSRSDHLSLHMRRH 362
            |||.|.|.|.:|.|.|.|||||:.|.|||
Human   448 HTGEKKFVCPVCDRRFMRSDHLTKHARRH 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	46/78 (59%)
		zf-C2H2	280..304	CDD:278523	14/23 (61%)
		C2H2 Zn finger	282..304	CDD:275368	14/21 (67%)
		zf-H2C2_2	296..>313	CDD:290200	13/16 (81%)
		C2H2 Zn finger	312..334	CDD:275368	14/21 (67%)
		zf-H2C2_2	326..351	CDD:290200	14/24 (58%)
		C2H2 Zn finger	342..362	CDD:275368	11/19 (58%)
KLF11	NP_003588.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		6/18 (33%)
		COG5048	393..>449	CDD:227381	35/56 (63%)
		zf-C2H2	394..418	CDD:278523	14/23 (61%)
		C2H2 Zn finger	399..418	CDD:275368	13/18 (72%)
		zf-H2C2_2	410..437	CDD:290200	18/26 (69%)
		C2H2 Zn finger	426..448	CDD:275368	14/21 (67%)
		zf-H2C2_2	440..463	CDD:290200	13/22 (59%)
		zf-C2H2	454..476	CDD:278523	12/21 (57%)
		C2H2 Zn finger	456..476	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010