DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and klf12a

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_021331523.1	Gene:	klf12a / 798629	ZFINID:	ZDB-GENE-030131-9188	Length:	380	Species:	Danio rerio

Alignment Length:	412	Identity:	128/412 - (31%)
Similarity:	164/412 - (39%)	Gaps:	155/412 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SDPLSAKEAEGPPVQVEPVDLSLRSPRASTSHGSSSS-SYKFSSANKAVGYSNGKPGGSSGSSSS 72
            |||..        .|.||||||....|.|.|..:||| |...||::.::.:....|..|....||
Zfish    59 SDPFQ--------TQTEPVDLSTNKARTSPSLSASSSLSSSPSSSSSSIRFCPRSPPSSKSLPSS 115

  Fly    73 SGFGAGSAGSSSLGAFAAQQQQQLYASSG---VSKLP---------------FSPFFAASPFFFT 119
            |........|||........:.::..|..   ||.||               ..|  .:||....
Zfish   116 SPSSLSMPSSSSTSVITPVPRLKMSPSCSVPVVSSLPSRGLRGQSFLHIPQLMPP--CSSPVHIH 178

  Fly   120 YRRI-----------SGSGS------------------------GNGTG---SVSVKQEDNNNSC 146
            .||:           .|.||                        .:|..   |:|..::|:..:.
Zfish   179 PRRVPVVVQPMPLVYPGVGSLGSSRLMMPLLEENRMHRKVMHRMADGLSPRRSLSDSEDDDLPNV 243

  Fly   147 SYNNGSSSGG-AGSAANSMQDYESKFSLLSLFKNPYKFAGGDGQASRKTSPTGGSSKPLASNSSP 210
            :..:.:.:|. |.:.|.::||....||:.||               |:..|
Zfish   244 TLESVNETGSTALTIARAVQDSLLPFSIESL---------------RRPRP-------------- 279

  Fly   211 SWKSYAGSGSPHAALNPAFGGMGRGATRKDNSSFSGINFGGGGSAFGFTTSSDSMANGGYNDLSK 275
                   |.||.                                                   ||
Zfish   280 -------SESPD---------------------------------------------------SK 286

  Fly   276 NRKVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKPF 340
            .|::|:|:.|||:||||||||||||:|||||||||.|||:.|.|:||||||||||||||||||||
Zfish   287 RRRIHRCEFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWDNCTWKFARSDELTRHYRKHTGVKPF 351

  Fly   341 RCQLCTRSFSRSDHLSLHMRRH 362
            :|..|.|||||||||:||.|||
Zfish   352 KCSDCDRSFSRSDHLALHRRRH 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	60/78 (77%)
		zf-C2H2	280..304	CDD:278523	18/23 (78%)
		C2H2 Zn finger	282..304	CDD:275368	17/21 (81%)
		zf-H2C2_2	296..>313	CDD:290200	14/16 (88%)
		C2H2 Zn finger	312..334	CDD:275368	17/21 (81%)
		zf-H2C2_2	326..351	CDD:290200	20/24 (83%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
klf12a	XP_021331523.1	SFP1	<217..370	CDD:227516	84/239 (35%)
		C2H2 Zn finger	296..315	CDD:275368	16/18 (89%)
		C2H2 Zn finger	323..345	CDD:275368	17/21 (81%)
		zf-H2C2_2	337..362	CDD:316026	20/24 (83%)
		C2H2 Zn finger	353..373	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11437
eggNOG	1	0.900	-	-		E33208_3BRQ6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3723
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1178
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.920