DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42741 and WT1

DIOPT Version :9

Sequence 1:NP_611747.2 Gene:CG42741 / 37654 FlyBaseID:FBgn0261705 Length:362 Species:Drosophila melanogaster
Sequence 2:NP_077744.4 Gene:WT1 / 7490 HGNCID:12796 Length:522 Species:Homo sapiens


Alignment Length:342 Identity:96/342 - (28%)
Similarity:137/342 - (40%) Gaps:85/342 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 SGFGAGSAGSSSLGAFAAQQQQQLYASSGVSKL-PFSPFFAASPFFFTYRRISGSGSGNGTGSVS 136
            ||...|:||:...|.|......|  ||||.::: |.:|:..:........|..|..:....|:.|
Human   170 SGQFTGTAGACRYGPFGPPPPSQ--ASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPS 232

  Fly   137 VKQEDNNNSCSYNNGSSSGGAGSAANSMQDYESKFSLLSLFK--NPYKFAGGDGQASRKTSPTGG 199
            .....::::..:.|.|                        ||  :|....|..|:......|   
Human   233 YGHTPSHHAAQFPNHS------------------------FKHEDPMGQQGSLGEQQYSVPP--- 270

  Fly   200 SSKPLASNSSPSWKSYAGS-----GSPHAALN----------PAFGGMGRGATRKD--NSSFSGI 247
               |:....:|: .|..||     .:|:::.|          ..:..|..|||.|.  ..|.|.:
Human   271 ---PVYGCHTPT-DSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSV 331

  Fly   248 NFGGGGSAFGFTTSSDS-------------MANGGYNDLSKNRKV-------------------H 280
            .:..|.|.......||:             ..:|.:..:...|:|                   .
Human   332 KWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPF 396

  Fly   281 KCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKPFRCQLC 345
            .|...||:|.|.|.|||:.|.|.|||||||.|.::.|..||:|||:|.||.|:|||||||:|:.|
Human   397 MCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTC 461

  Fly   346 TRSFSRSDHLSLHMRRH 362
            .|.|||||||..|.|.|
Human   462 QRKFSRSDHLKTHTRTH 478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42741NP_611747.2 COG5048 <273..>352 CDD:227381 43/97 (44%)
zf-C2H2 280..304 CDD:278523 11/23 (48%)
C2H2 Zn finger 282..304 CDD:275368 11/21 (52%)
zf-H2C2_2 296..>313 CDD:290200 11/16 (69%)
C2H2 Zn finger 312..334 CDD:275368 11/21 (52%)
zf-H2C2_2 326..351 CDD:290200 15/24 (63%)
C2H2 Zn finger 342..362 CDD:275368 12/19 (63%)
WT1NP_077744.4 WT1 74..394 CDD:308009 47/256 (18%)
COG5048 386..>514 CDD:227381 49/93 (53%)
C2H2 Zn finger 401..420 CDD:275368 10/18 (56%)
C2H2 Zn finger 428..450 CDD:275368 11/21 (52%)
C2H2 Zn finger 458..478 CDD:275368 12/19 (63%)
C2H2 Zn finger 489..511 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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