DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and klf8

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_001073472.1	Gene:	klf8 / 562805	ZFINID:	ZDB-GENE-070424-152	Length:	343	Species:	Danio rerio

Alignment Length:	373	Identity:	121/373 - (32%)
Similarity:	157/373 - (42%)	Gaps:	106/373 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DPLSAKEAEGPPV------------QVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGK 62
            :|...|....||.            |.|||||||..||.|....:::|:           .:|..
Zfish    54 EPTDLKIKSSPPPLCIISTQHSDADQTEPVDLSLNKPRPSLPIATATST-----------PANLP 107

  Fly    63 PGGSSGSSS-SSGFGAGSAGSSSLGAFAAQQQQQLYA------SSGVSKLPFSPFFAAS-PFFFT 119
            |...:.|:: .:....||..:|:.|....|....::.      .|.:.:|...|....| |..:|
Zfish   108 PQNITASATIPAVLSQGSILASTQGVGGQQILHVIHTIPSVNMPSKLGQLQTIPVVVQSLPVVYT 172

  Fly   120 YRRISGSGSGNGTGSVSVKQEDNNNSCSYNNGSSSGGAGSAANSMQDYESKFSLLSLFKNPYKFA 184
                :....|..|.:::|                                            ...
Zfish   173 ----TVPTDGMATAAITV--------------------------------------------PLI 189

  Fly   185 GGDGQASRKTSPTGGSSKPLASNSSPSWKSYAGSGSPHAALNPAFGGMGRGATRKDNSSFSGINF 249
            |.||::........||:.|:...|....:|...|||                          .:|
Zfish   190 GSDGRSEGSVRIKPGSTSPVEYQSESDAESGTESGS--------------------------ASF 228

  Fly   250 GGGGSAFGFTTSSDSMANGGYNDLSKNRKVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTW 314
            ...|......|..|..|:....|: |.|:||.||.:||:||||||||||||:|.|||||||.|||
Zfish   229 STQGMEPSINTDVDIPADPDSPDM-KRRRVHMCDYDGCNKVYTKSSHLKAHRRIHTGEKPYQCTW 292

  Fly   315 EGCIWRFARSDELTRHYRKHTGVKPFRCQLCTRSFSRSDHLSLHMRRH 362
            |||.||||||||||||:|||||:|||||..|.|||||||||:||.|||
Zfish   293 EGCTWRFARSDELTRHFRKHTGIKPFRCTDCDRSFSRSDHLALHRRRH 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	61/78 (78%)
		zf-C2H2	280..304	CDD:278523	18/23 (78%)
		C2H2 Zn finger	282..304	CDD:275368	17/21 (81%)
		zf-H2C2_2	296..>313	CDD:290200	13/16 (81%)
		C2H2 Zn finger	312..334	CDD:275368	19/21 (90%)
		zf-H2C2_2	326..351	CDD:290200	19/24 (79%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
klf8	NP_001073472.1	repressor motif	82..86		3/3 (100%)
		zf-C2H2	258..282	CDD:278523	18/23 (78%)
		C2H2 Zn finger	260..282	CDD:275368	17/21 (81%)
		COG5048	<265..>330	CDD:227381	54/64 (84%)
		zf-H2C2_2	274..>291	CDD:290200	13/16 (81%)
		C2H2 Zn finger	290..312	CDD:275368	19/21 (90%)
		zf-H2C2_2	304..329	CDD:290200	19/24 (79%)
		C2H2 Zn finger	320..340	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10737
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto39976
orthoMCL	1	0.900	-	-		OOG6_114047
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5802
SonicParanoid	1	1.000	-	-		X1178
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.900