DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and klf4

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_001017280.1	Gene:	klf4 / 550034	XenbaseID:	XB-GENE-1015049	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	410	Identity:	127/410 - (30%)
Similarity:	167/410 - (40%)	Gaps:	111/410 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GLGSDPLSAKEAEGPPVQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKPGGSSGSS 70
            |..|...|...:..||....|          .|....||::..|.       |....|..|||.:
Frog    55 GSSSSSSSVTASSPPPPATLP----------DTMSALSSTTCNFV-------YQVRCPQESSGGT 102

  Fly    71 ----------SSSGFGAGSAGS-SSLGAFAAQ----------QQQQLYAS--------------- 99
                      ||:.|....... |..|.|.|:          .|||..||
Frog   103 LMYNARDPTMSSATFNLADINDVSPSGGFVAELMRPDLDPVFMQQQPQASLQGKFVLKTTVSMGD 167

  Fly   100 -----------SGVSKLPFSPFFAASPFFFTYRRISGSGSGNGTGSVSVKQEDNNNSCSYNNGSS 153
                       ||:.          ||..:|..::.       .....:|||. ::||:  :...
Frog   168 YGQTISVRKNNSGID----------SPLSYTTHQLP-------RVCQKIKQEP-SSSCT--SACP 212

  Fly   154 SGGAGSAANSMQDYESKFSL-----LSLFKNPYKFAGGDGQASRKTSPTGGSSKPLASNSSPSWK 213
            ..|.|..:.||:::::...|     .||  :|.:..|.|..:|.:|........|.|.::|.|:
Frog   213 MDGQGQQSQSMREFQAGRGLPIRTNQSL--SPEELMGRDCHSSSQTLSHSSLPIPPAYHTSASF- 274

  Fly   214 SYAGSGSPHAALNPAFGGMGRGATRKDNSSFSGINFGGGGSAFGFTTSSDSMANGGYNDLSKNR- 277
            |:..|..|...|.|.            ...:..:...||      ....:|....|.....:.|
Frog   275 SHFTSDQPQTQLPPT------------QLQYQELLTTGG------CIPEESKPKRGRKSWPRKRT 321

  Fly   278 KVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKPFRC 342
            ..|.|:..||.|.||||||||||.|||||||||.|.||||.|:||||||||||||||||.:||:|
Frog   322 ATHTCEYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWEGCGWKFARSDELTRHYRKHTGHRPFQC 386

  Fly   343 QLCTRSFSRSDHLSLHMRRH 362
            |.|.|:|||||||:|||:||
Frog   387 QRCDRAFSRSDHLALHMKRH 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	55/79 (70%)
		zf-C2H2	280..304	CDD:278523	16/23 (70%)
		C2H2 Zn finger	282..304	CDD:275368	15/21 (71%)
		zf-H2C2_2	296..>313	CDD:290200	14/16 (88%)
		C2H2 Zn finger	312..334	CDD:275368	18/21 (86%)
		zf-H2C2_2	326..351	CDD:290200	18/24 (75%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
klf4	NP_001017280.1	zf-C2H2	324..348	CDD:333835	16/23 (70%)
		C2H2 Zn finger	326..348	CDD:275368	15/21 (71%)
		C2H2 Zn finger	356..378	CDD:275368	18/21 (86%)
		zf-H2C2_2	370..395	CDD:372612	18/24 (75%)
		C2H2 Zn finger	386..406	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010